银屑病中鳞状细胞癌抗原的免疫组织化学研究
Squamous Cell Carcinoma Antigen in Psoriasis: An Immunohistochemical Study.
作者信息
Ghonemy Soheir, Mohamed Basma, Elkashishy Kamal, Ibrahim Al-Shimaa M
机构信息
All authors are with the Faculty of Medicine, Zagazig University in Zagazig, Egypt.
出版信息
J Clin Aesthet Dermatol. 2021 Sep;14(9):50-53.
BACKGROUND
Squamous cell carcinoma antigens (SCCA1, SCCA2) are members of the ovalbumin serpin family that have been described as biomarkers of squamous cell carcinomas. Different studies to date have stated the involvement of SCCA in the pathogenesis of certain immunological diseases, such as asthma and atopic dermatitis.
OBJECTIVE
We sought to assess the expression of SCCA2 in the skin of patients with chronic plaque psoriasis and to detect its correlation with the clinical severity of psoriasis and with the density of inflammatory infiltrates in the skin lesions.
METHODS
Skin biopsies were taken from 24 patients with psoriasis vulgaris and 24 healthy controls by 5-mm punches. Tissues were stained with hematoxylin and eosin to confirm the diagnosis and to assess the grade of inflammation. The expression level of SCCA2 in the skin was assessed by immunohistochemical analysis.
RESULTS
The tissue SCCA2 level was significantly higher in psoriatic patients than controls and correlated positively with the severity of psoriasis. In addition, the dermal SCCA2 expression correlated positively with the density of dermal inflammatory infiltrates.
CONCLUSION
SCCA2 could be a useful marker of the clinical severity and the grade of inflammation of psoriasis.
背景
鳞状细胞癌抗原（SCCA1、SCCA2）是卵清蛋白丝氨酸蛋白酶抑制剂家族的成员，已被描述为鳞状细胞癌的生物标志物。迄今为止，不同的研究表明SCCA参与了某些免疫性疾病的发病机制，如哮喘和特应性皮炎。
目的
我们试图评估慢性斑块状银屑病患者皮肤中SCCA2的表达，并检测其与银屑病临床严重程度以及皮肤病变中炎症浸润密度的相关性。
方法
用5毫米打孔器从24例寻常型银屑病患者和24例健康对照者身上取皮肤活检组织。组织用苏木精和伊红染色以确诊并评估炎症程度。通过免疫组织化学分析评估皮肤中SCCA2的表达水平。
结果
银屑病患者的组织SCCA2水平显著高于对照组，且与银屑病的严重程度呈正相关。此外，真皮SCCA2表达与真皮炎症浸润密度呈正相关。
结论
SCCA2可能是银屑病临床严重程度和炎症程度的有用标志物。
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