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额部纤维性秃发:男性中与硬化性苔藓的一种新关联。

Frontal Fibrosing Alopecia: A New Association with Lichen Sclerosus in Men.

作者信息

Rossi Alfredo, Tadiotto Cicogna Giulia, Caro Gemma, Fortuna Maria Caterina, Magri Francesca, Grassi Sara

机构信息

Drs. Rossi, Fortuna, Caro, Magri, and Grassi are with the Department of Internal Medicine and Medical Specialties, Dermatology at the Sapienza University of Rome in Rome, Italy.

Dr. Tadiotto Cicogna is with the Unit of Dermatology at the University of Padua in Padua, Italy.

出版信息

J Clin Aesthet Dermatol. 2021 Sep;14(9):54-58.

Abstract

BACKGROUND

Frontal fibrosing alopecia (FFA) is a scarring alopecia that has been reported mostly in postmenopausal women and is characterized by frontotemporal hairline. Currently, there are only a few reports about FFA in male patients.

OBJECTIVE

This study sought to analyze clinical and trichoscopic features of FFA in a case series of men and to describe the main features of FFA in male patients through a review of the literature.

METHODS

Male patients with clinical and trichoscopical signs of FFA, histologically confirmed, who attended to our clinic from 2014 to 2019 were included in our study. From each patient, clinical and trichoscopic data were collected.

RESULTS

Eight men with an average age of 59 years were recruited. In five patients, serrated hairline recession (i.e., a "zig-zag" pattern) was present, while three presented with linear hairline recession. Also, the eyebrows (n=3 patients), sideburns (n=2 patients), and beard (n=2 patients) were involved. Surprisingly, in two patients, an association with lichen sclerosus (LS) was present.

CONCLUSION

To the best of our knowledge, this is the first report of a serrated hairline recession pattern in male patients with FFA. A new association between FFA and LS in men was also found. Further studies need to establish the extent of this association and facilitate a better comprehension of the pathophysiologic mechanisms underlying these two diseases.

摘要

背景

额部纤维性秃发(FFA)是一种瘢痕性秃发,主要见于绝经后女性,其特征为额颞部发际线。目前,关于男性患者FFA的报道较少。

目的

本研究旨在分析一组男性FFA患者的临床和毛发镜特征,并通过文献回顾描述男性患者FFA的主要特征。

方法

纳入2014年至2019年在我院就诊、临床和毛发镜检查有FFA体征且经组织学证实的男性患者。收集每位患者的临床和毛发镜数据。

结果

招募了8名平均年龄为59岁的男性。5例患者出现锯齿状发际线后移(即“之”字形模式),3例出现直线状发际线后移。此外,眉毛(3例患者)、鬓角(2例患者)和胡须(2例患者)也受累。令人惊讶的是,2例患者合并有硬化性苔藓(LS)。

结论

据我们所知,这是男性FFA患者出现锯齿状发际线后移模式的首例报道。还发现了男性FFA与LS之间的新关联。需要进一步研究以确定这种关联的程度,并有助于更好地理解这两种疾病的病理生理机制。

相似文献

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Frontal fibrosing alopecia among men: A clinicopathologic study of 7 cases.男性额部纤维性脱发:7 例临床病理研究。
J Am Acad Dermatol. 2017 Oct;77(4):683-690.e2. doi: 10.1016/j.jaad.2017.05.045. Epub 2017 Jul 14.
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Frontal Fibrosing Alopecia: Update and Review of Challenges and Successes.额部纤维性脱发:挑战与成功的更新与回顾。
J Cutan Med Surg. 2018 Mar/Apr;22(2):182-189. doi: 10.1177/1203475417736279. Epub 2017 Oct 23.

引用本文的文献

本文引用的文献

1
Frontal fibrosing alopecia in males: demographics, clinical profile and treatment experience.
J Eur Acad Dermatol Venereol. 2020 Feb;34(2):e101-e104. doi: 10.1111/jdv.15971.
4
Familial frontal fibrosing alopecia in two male families.两个男性家族中的家族性额部纤维性秃发
Int J Dermatol. 2019 Sep;58(9):e178-e180. doi: 10.1111/ijd.14499. Epub 2019 Jun 5.
5
First Italian case of frontal fibrosing alopecia in a male.意大利首例男性额部纤维性秃发病例。
Ital J Dermatol Venerol. 2021 Dec;156(Suppl. 1 to No. 6):32-33. doi: 10.23736/S2784-8671.19.06286-2. Epub 2019 Feb 4.
6
Case Report of Connubial Frontal Fibrosing Alopecia.婚姻性额部纤维性脱发病例报告
Int J Trichology. 2018 Mar-Apr;10(2):76-79. doi: 10.4103/ijt.ijt_105_17.
10
Frontal fibrosing alopecia among men: A clinicopathologic study of 7 cases.男性额部纤维性脱发:7 例临床病理研究。
J Am Acad Dermatol. 2017 Oct;77(4):683-690.e2. doi: 10.1016/j.jaad.2017.05.045. Epub 2017 Jul 14.

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