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[撤回] 环状RNA CSNK1G1通过靶向miR-4428/FUT2轴促进骨关节炎进展。

[Retracted] Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR‑4428/FUT2 axis.

作者信息

Xiao Jianwei, Wang Rongsheng, Zhou Weijian, Cai Xu, Ye Zhizhong

机构信息

Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, Guangdong 518000, P.R. China.

Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 200000, P.R. China.

出版信息

Int J Mol Med. 2022 Mar;49(3). doi: 10.3892/ijmm.2022.5080. Epub 2022 Jan 4.

Abstract

Following the publication of the above paper, upon having repeated some of the experiments and contrary to the results reported in the article, the authors have found that the expression of FUT2 did not decrease in the circCSNK1G1 knockdown rat model of osteoarthritis, and furthermore, the expression of FUT2 in the AMO‑4428 group was not increased compared with the control group. Moreover, the results of the Bcl‑2/BAX experiments assessed by western blot analysis and the percentages of apoptotic cells detected by flow cytometry assay in the '' subsection were performed by an external biotechnology company, and they have not been able to provide the raw data upon the authors submitting a request for these.Therefore, the authors have requested that the paper be retracted on account of a lack of confidence in the presented data. The Editor of has agreed with the authors that this paper should be retracted from the Journal. All the authors agree to the retraction of this paper. The Editor and the authors apologize to the readership for any inconvenience caused. [the original article was published in 47: 232‑242, 2021; DOI: 10.3892/ijmm.2020.4772].

摘要

在上述论文发表后,作者重复了部分实验,结果与文章报道的结果相反,发现在骨关节炎的circCSNK1G1敲低大鼠模型中FUT2的表达并未降低,此外,与对照组相比,AMO-4428组中FUT2的表达也没有增加。此外,“小节”中通过蛋白质免疫印迹分析评估的Bcl-2/BAX实验结果以及通过流式细胞术检测的凋亡细胞百分比是由外部生物技术公司进行的,作者要求提供这些原始数据时,他们无法提供。因此,由于对所呈现的数据缺乏信心,作者要求撤回该论文。《》的编辑同意作者的意见,认为这篇论文应从该期刊撤回。所有作者均同意撤回本文。编辑和作者就所造成的任何不便向读者表示歉意。[原文发表于《》47: 232-242, 2021; DOI: 10.3892/ijmm.2020.4772]

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