College of Plant Health and Medicine, Qingdao Agricultural University, Qingdao 266109, China.
Phytopathology. 2022 Jun;112(6):1264-1272. doi: 10.1094/PHYTO-11-21-0483-R. Epub 2022 May 4.
causes gray mold resulting in enormous financial loss. Fungicide resistance of . has become a serious issue in food safety and agricultural environmental protection. Sodium valproate (SV) has been used in clinical trials; thus, it is an excellent candidate for fungicide development, considering its safety. However, the antifungal activity remains unclear. SV was effective against by enhancing acetylation of histone H3, including H3K9ac, H3K14ac, and H3K56ac. A transcriptomics analysis revealed that the expression of 1,557 genes changed significantly in response to SV. A pathway enrichment analysis identified 16 significant GO terms, in which molecular functions were mainly involved. In addition, the expression levels of 13 genes involved in virulence and five genes involved in tomato immune response were altered by the SV treatment. These results indicate that SV inhibits by enhancing acetylation of histone H3 and modifying gene transcription. Thus, SV is an effective, safe, potential antifungal agent for control of both pre- and postharvest losses caused by
导致灰霉病，造成巨大的经济损失。. 的抗药性已成为食品安全和农业环境保护的严重问题。丙戊酸钠（SV）已在临床试验中使用；因此，考虑到其安全性，它是开发杀真菌剂的绝佳候选药物。但是，抗真菌活性尚不清楚。SV 通过增强组蛋白 H3 的乙酰化（包括 H3K9ac、H3K14ac 和 H3K56ac）来有效抵抗. 通过转录组学分析，发现 1557 个基因的表达因 SV 而显著变化。途径富集分析确定了 16 个显著的 GO 术语，其中主要涉及分子功能。此外，SV 处理还改变了 13 个与毒性相关的基因和 5 个与番茄免疫反应相关的基因的表达水平。这些结果表明，SV 通过增强组蛋白 H3 的乙酰化和修饰基因转录来抑制. 因此，SV 是一种有效、安全、有潜力的抗真菌剂，可控制由引起的采前和采后损失
