Ag-TiO Nanoparticles-catalyzed Three-component Synthesis of 12-aryl- 8,9,10,12-tetrahydrobenzo[a]-Xanthen-11-ones in Aqueous Medium.

BACKGROUND

Ag-TiO nanoparticles catalyzed synthesis of 12-aryl-8,9,10,12- tetrahydrobenzo[a]-xanthen-11-ones have been enhanced via a three-component one-pot reaction betweenβ-naphthol, several aldehydes and dimedone in HO at room temperature. Xanthenes are essential intermediates in chemistry owing to their vast difference in biological activity.

METHODS

This process offered significant advantages containing appropriate cost efficiency, low amount of the catalyst, application of low-cost available Ag-TiO nanoparticles catalyst, purification of the product by non-chromatographic method, easy process, good atom economy, simple isolation and reusability of nanocatalyst.

RESULTS

Ag-TiO nanoparticles catalyst shows easy access to Xanthenes with appropriate yields in short reaction time and purity. This nanoparticles catalyst was recycled and recovered by easy filtration and was reused up to five times with only an unimportant loss in its catalytic efficacy.

CONCLUSION

This method achieves to have a numerous scope relating to the difference in the aldehydes. Correspondingly, the attractiveness of this research was that HO was the only by-product.