Payen J F, Riondel J P, Denis M J, Doublier C, Badji R, Arvieux C, Stieglitz P
Ann Fr Anesth Reanim. 1987;6(4):293-6. doi: 10.1016/s0750-7658(87)80043-6.
The clinical effects of propofol and methohexitone were compared in a group of 59 women undergoing abortion under general anaesthesia. At induction, the premedicated patients were given 2.5 mg . kg-1 propofol or methohexitone, followed by 1 mg . kg-1 fentanyl; if necessary, extra bolus doses of hypnotic were given. Hiccups and other movements were more frequent with methohexitone. There was no difference between the two groups as for injection pain and apnoea. The quicker recovery with propofol, with a mean of 2 min less, even when extra doses were given, could be explained by the pharmacokinetics of the drug. However, the quality of recovery in either group was satisfactory for short-length anaesthesia.
在一组59名接受全身麻醉下人工流产的女性中，比较了丙泊酚和甲己炔巴比妥的临床效果。诱导时，预先用药的患者给予2.5mg·kg-1丙泊酚或甲己炔巴比妥，随后给予1mg·kg-1芬太尼；必要时，给予额外的催眠药推注剂量。甲己炔巴比妥组的呃逆和其他动作更频繁。两组在注射疼痛和呼吸暂停方面无差异。即使给予额外剂量，丙泊酚的恢复更快，平均少2分钟，这可以用药物的药代动力学来解释。然而，两组的恢复质量对于短时长麻醉来说都是令人满意的。
