Hafler D A, Weiner H L
Ann Neurol. 1987 Jul;22(1):89-93. doi: 10.1002/ana.410220121.
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). In MS patients being treated with anti-T11, a murine monoclonal antibody which recognizes the sheep red blood cell receptor, it was found that peripheral blood T cells were labeled in vivo by the antibody. Furthermore, anti-T11 did not lyse cells or enter the cerebrospinal fluid (CSF). In CSF specimens obtained by serial lumbar punctures from patients with progressive MS who received five daily infusions of anti-T11, 70 +/- 12% of the T cells had mouse antibody bound to their surface by 72 to 96 hours. No in vivo staining of CSF T cells was observed in patients infused with anti-T4, a murine monoclonal antibody that was not found to label T cells in vivo. These results demonstrate that there is rapid movement of lymphocytes from the peripheral blood to the CNS in patients with progressive MS. This rapid trafficking of T cells suggests that the ongoing pathological process within the CNS may be closely linked to the peripheral immune system and may have implications for the monitoring and treatment of MS.
多发性硬化症（MS）是一种中枢神经系统（CNS）的炎症性疾病。在用抗T11（一种识别绵羊红细胞受体的鼠单克隆抗体）治疗的MS患者中，发现外周血T细胞在体内被该抗体标记。此外，抗T11不会裂解细胞或进入脑脊液（CSF）。在接受每日五次抗T11输注的进行性MS患者通过连续腰椎穿刺获得的CSF标本中，到72至96小时时，70±12%的T细胞表面结合有鼠抗体。在输注抗T4（一种未发现能在体内标记T细胞的鼠单克隆抗体）的患者中未观察到CSF T细胞的体内染色。这些结果表明，进行性MS患者的淋巴细胞从外周血快速迁移至CNS。T细胞的这种快速运输表明，CNS内正在进行的病理过程可能与外周免疫系统密切相关，并且可能对MS的监测和治疗具有影响。
