The Interdisciplinary Stem Cell Institute, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Epigenetics and Stem Cell Unit, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
J Gerontol A Biol Sci Med Sci. 2022 Jul 5;77(7):1292-1294. doi: 10.1093/gerona/glac003.
While there is extensive interest in geroscience approaches to health and disease, few basic science discoveries have made their way into clinical trials. Herein, we comment on cell-based therapies, in which supplementing robust stem cell capacity to aged systems theoretically could lead to sustained improvement. This exciting approach has undergone translational development, and we highlight studies targeting a single system and others aimed at treating overall aging frailty by restoring the aged stem cell niches that underly diminished endogenous regenerative capacity.
尽管人们对衰老科学在健康和疾病方面的应用方法很感兴趣，但很少有基础科学发现能够进入临床试验。在此，我们对基于细胞的疗法进行评论，理论上，补充强健的干细胞能力可以使老年系统得到持续改善。这种令人兴奋的方法已经经历了转化发展，我们重点介绍了针对单一系统的研究，以及通过恢复基础的衰老干细胞生态位来治疗整体衰老虚弱的研究，这些生态位是导致内源性再生能力减弱的原因。
