Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Elife. 2022 Jan 5;11:e67007. doi: 10.7554/eLife.67007.
Predator exposure is a life-threatening experience and elicits learned fear responses to the context in which the predator was encountered. The anterior cingulate area (ACA) occupies a pivotal position in a cortical network responsive to predatory threats, and it exerts a critical role in processing fear memory. The experiments were made in mice and revealed that the ACA is involved in both the acquisition and expression of contextual fear to predatory threat. Overall, the ACA can provide predictive relationships between the context and the predator threat and influences fear memory acquisition through projections to the basolateral amygdala and perirhinal region and the expression of contextual fear through projections to the dorsolateral periaqueductal gray. Our results expand previous studies based on classical fear conditioning and open interesting perspectives for understanding how the ACA is involved in processing contextual fear memory to ethologic threatening conditions that entrain specific medial hypothalamic fear circuits.
捕食者暴露是一种危及生命的经历，并会引发对遭遇捕食者的情境的习得性恐惧反应。前扣带皮层（ACA）在对捕食威胁有反应的皮质网络中占据关键位置，并且在处理恐惧记忆方面发挥着关键作用。这些实验是在老鼠身上进行的，结果表明 ACA 参与了对捕食威胁的情境性恐惧的获得和表达。总的来说，ACA 可以提供上下文和捕食者威胁之间的预测关系，并通过投射到基底外侧杏仁核和边缘区以及投射到背外侧导水管周围灰质来影响恐惧记忆的获得，从而影响情境性恐惧的表达。我们的研究结果扩展了基于经典恐惧条件反射的先前研究，并为理解 ACA 如何参与处理与特定内侧下丘脑恐惧回路相关的生态威胁条件下的情境性恐惧记忆提供了有趣的视角。
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