Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA 02215, USA.
Division of Material Science and Engineering, Boston University, Brookline, MA 02446, USA.
Soft Matter. 2022 Jan 19;18(3):680-682. doi: 10.1039/d1sm01495a.
Drs Humphrey and Cyron wrote a commentary regarding our review article entitled "Tensional homeostasis at different length scales" that was published in , 2020, , 6946-6963. These authors brought up some valid concerns to which we would like to respond. Their first concern is related to our remark regarding equations that we used to describe homeostasis in blood vessels, where we stated that those equations were limited only to linearly elastic materials. We were wrong, and we agree with the authors that these equations hold for all cylindrical vessels regardless of their material properties. Their second concern is related to tensional homeostasis at the subcellular level. Drs Humphrey and Cyron disagree with our substantiated claim that tensional homeostasis breaks down at the level of focal adhesions (FAs) of a living cell. In our reply, we provided several pieces of evidence that demonstrate that tensional homeostasis depends upon FA size, FA maturity and FA force dynamics and thus, tensional homeostasis cannot hold in all FAs across a cell. In summary, we are grateful for the opportunity to reply to the commentary of Drs Humphrey and Cyron. Moreover, we are excited that this topic has become an important focus in the biomechanics and mechanobiology communities, and we feel strongly that critical feedback is necessary to move this field forward.
汉弗莱博士和赛伦博士就我们发表在 2020 年第 6946-6963 期《 》上的题为“不同尺度的紧张性稳态”的综述文章写了一篇评论。这些作者提出了一些我们需要回应的合理关切。他们的第一个关切与我们用来描述血管内稳态的方程有关，我们在评论中指出这些方程仅适用于线性弹性材料。我们错了，我们同意作者的观点，即这些方程适用于所有圆柱形血管，而与它们的材料特性无关。他们的第二个关切与细胞水平的紧张性稳态有关。汉弗莱博士和赛伦博士不同意我们有充分根据的说法，即紧张性稳态在活细胞的黏着斑（FAs）水平上崩溃。在我们的回复中，我们提供了一些证据，证明紧张性稳态取决于 FA 的大小、FA 的成熟度和 FA 的力动力学，因此，紧张性稳态不可能在细胞中的所有 FA 中保持。总之，我们很感谢有机会回复汉弗莱博士和赛伦博士的评论。此外，我们很高兴这个话题已经成为生物力学和机械生物学领域的一个重要焦点，我们强烈认为，为了推动这个领域的发展，批判性的反馈是必要的。
