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DNA病毒感染对RLR信号通路的激活与逃逸

Activation and Evasion of RLR Signaling by DNA Virus Infection.

作者信息

Jia Junli, Fu Jiangan, Tang Huamin

机构信息

Department of Immunology, Nanjing Medical University, Nanjing, China.

Genor Biopharma Co., Ltd., Shanghai, China.

出版信息

Front Microbiol. 2021 Dec 20;12:804511. doi: 10.3389/fmicb.2021.804511. eCollection 2021.

DOI:10.3389/fmicb.2021.804511
PMID:34987495
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8721196/
Abstract

Antiviral innate immune response triggered by nucleic acid recognition plays an extremely important role in controlling viral infections. The initiation of antiviral immune response against RNA viruses through ligand recognition of retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) was extensively studied. RLR's role in DNA virus infection, which is less known, is increasing attention. Here, we review the research progress of the ligand recognition of RLRs during the DNA virus infection process and the viral evasion mechanism from host immune responses.

摘要

由核酸识别引发的抗病毒天然免疫反应在控制病毒感染中起着极其重要的作用。通过视黄酸诱导基因I（RIG-I）样受体（RLR）的配体识别来启动针对RNA病毒的抗病毒免疫反应已得到广泛研究。RLR在DNA病毒感染中的作用鲜为人知，但正日益受到关注。在此，我们综述了DNA病毒感染过程中RLR配体识别的研究进展以及病毒逃避宿主免疫反应的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/192d/8721196/d6d49037104d/fmicb-12-804511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/192d/8721196/d6d49037104d/fmicb-12-804511-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/192d/8721196/d6d49037104d/fmicb-12-804511-g001.jpg

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