关于维生素 B 补充剂治疗糖尿病周围神经病变疗效的系统评价。
A systematic review on the efficacy of vitamin B supplementation on diabetic peripheral neuropathy.
机构信息
Postdoctoral Research Fellow, Lebanese American University Medical Center, Beirut, Lebanon.
Department of Orthopedic Surgery, Lebanese American University Medical Center-Rizk Hospital; Diabetic Foot Clinic; and the Center for Evidence-Based Anatomy, Sport & Orthopedic Research, Lebanese American University, School of Medicine, Beirut, Lebanon.
出版信息
Nutr Rev. 2022 Apr 8;80(5):1340-1355. doi: 10.1093/nutrit/nuab116.
CONTEXT
Diabetic peripheral neuropathy (DPN) is a common complication.
OBJECTIVE
To re-evaluate the role of vitamin B supplementation on reducing the signs and symptoms of DPN.
DATA SOURCES
Electronic databases such as PubMed, Cochrane Library, and Medline.
DATA EXTRACTION
An Excel spreadsheet was used to report the extracted relevant data.
DATA ANALYSIS
Fourteen randomized controlled trials were selected, comprising a pooled sample of 997 study subjects. The pooled odds ratio values were 3.1 (95%CI, 1.197-8.089) and 3.04 (95%CI, 1.556-5.937) for pain and dysesthesia outcomes, respectively. For the amplitude change in electromyography of the sensory sural nerve, the weighted difference from 2 studies was 0.37 (95%CI, 0.034-0.709) in favor of intervention. Peak latency changes were in favor of the intervention group. Two studies yielded a weighted difference of 0.571 (95%CI, 0.310-0.831) for the velocity outcome in favor of intervention. Unlike the fibular nerve, the electromyographic motor outcomes of the tibial nerve were in favor of vitamin B supplementation.
CONCLUSION
Vitamin B supplementation could improve many symptoms and signs of DPN.
背景
糖尿病周围神经病变（DPN）是一种常见的并发症。
目的
重新评估维生素 B 补充剂在减轻 DPN 症状和体征方面的作用。
资料来源
电子数据库，如 PubMed、Cochrane 图书馆和 Medline。
资料提取
使用 Excel 电子表格报告提取的相关数据。
数据分析
选择了 14 项随机对照试验，共纳入 997 例研究对象。汇总的优势比（OR）值分别为 3.1（95%CI，1.197-8.089）和 3.04（95%CI，1.556-5.937），用于评估疼痛和感觉异常结局。对于体感腓肠神经的肌电图振幅变化，2 项研究的加权差值为 0.37（95%CI，0.034-0.709），表明干预措施有效。潜伏期变化有利于干预组。有 2 项研究的加权差值为 0.571（95%CI，0.310-0.831），表明干预措施有利于改善神经传导速度。与腓总神经不同，维生素 B 补充剂有利于改善胫神经的肌电图运动结果。
结论
维生素 B 补充剂可改善 DPN 的许多症状和体征。
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