Ichiyasu A, Takaoka M, Makino H, Takahashi K, Ota Z
Third Department of Internal Medicine, Okayama University Medical School, Japan.
Acta Med Okayama. 1987 Aug;41(4):183-5. doi: 10.18926/AMO/31729.
Rat kidney glomerular basement membrane (GBM) was isolated and digested with alpha-amylase and elastase. Electron microscopy revealed a meshwork structure composed of fibrils 3 nm in width. They appeared to be type IV collagen fibrils. We succeeded in clarifying a significant ultrastructural aspect of the GBM which had been unclear until now. The findings are consistent with our previously proposed GBM molecular sieve theory.
