大托叶云实根中的贝壳杉烷型二萜及其抗炎活性。
Cassane-type diterpenes from roots of Pterolobium macropterum and their anti-inflammatory activity.
机构信息
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Evin, Tehran, Iran.
出版信息
Phytochemistry. 2022 Apr;196:113074. doi: 10.1016/j.phytochem.2021.113074. Epub 2022 Jan 3.
Eight undescribed cassane diterpenes, pterolobirins C-J, together with two known analogs, were isolated from the roots of Pterolobium macropterum. Their structures were characterized by extensive spectroscopic techniques including NMR, MS, ECD and X-ray crystallographic spectroscopy. The absolute configuration of pterolobirin J was confirmed by single-crystal X-ray diffraction data. The compounds were screened for their anti-inflammatory activity on the lipopolysaccharide (LPS) induced nitric oxide (NO) production in J774. A1 macrophage cells. Pterolobirin E and sucutinirane C displayed good NO inhibition with IC values of 24.44 ± 1.34 and 19.16 ± 1.22 μM, respectively.
从大翼豆的根部分离得到了 8 个未被描述的贝壳杉二萜类化合物，即 pterolobirins C-J，以及两个已知的类似物。通过 NMR、MS、ECD 和 X 射线晶体学光谱等多种光谱技术对它们的结构进行了表征。通过单晶 X 射线衍射数据确定了 pterolobirin J 的绝对构型。对这些化合物进行了筛选，以检测它们对 LPS 诱导的 J774. A1 巨噬细胞中一氧化氮（NO）生成的抗炎活性。pterolobirin E 和 sucutinirane C 表现出良好的 NO 抑制作用，IC 值分别为 24.44±1.34 μM 和 19.16±1.22 μM。
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