de Souza J M, Heizmann P, Schwartz D E
Bull World Health Organ. 1987;65(3):353-6.
Ten male subjects from a region of the state of Pará, Brazil, where malaria is endemic received a single oral dose of 1000 mg mefloquine. The plasma levels of the drug and of its metabolite, 2,8-bis(trifluoromethyl)-4-quinolinecarboxylic acid, were determined densitometrically on thin-layer chromatography plates. The pharmacokinetic parameters obtained fell well within the range of values reported previously for Africans and Caucasians.
来自巴西帕拉州一个疟疾流行地区的10名男性受试者口服了1000毫克甲氟喹的单剂量药物。在薄层色谱板上用密度测定法测定了该药物及其代谢物2,8-双（三氟甲基）-4-喹啉羧酸的血浆水平。所获得的药代动力学参数完全落在先前报道的非洲人和高加索人的数值范围内。
