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吸烟对种植体周围龈沟液骨碱性磷酸酶和种植体稳定性的影响在加载前。

Effects of smoking on the bone alkaline phosphatase in peri-implant crevicular fluid and implant stability quotient around implants before loading.

机构信息

Faculty of Dentistry, Department of Periodontology, Gazi University, Biskek Cad. 82. Sok. Emek, Ankara, Turkey.

Faculty of Dentistry, Department of Prosthodontics, Gazi University, Ankara, Turkey.

出版信息

Odontology. 2022 Jul;110(3):596-604. doi: 10.1007/s10266-021-00685-2. Epub 2022 Jan 6.

DOI:10.1007/s10266-021-00685-2
PMID:34993689
Abstract

We aimed to examine the implant stability quotient (ISQ), alveolar bone level measurements (ABL), and bone alkaline phosphatase (BALP) in peri-implant crevicular fluid (PICF) around implants in smokers and non-smokers before loading in 3 months. 44 dental implants were placed into smoker and non-smoker patients equally. ISQ was measured at baseline and 3 months after surgery. The levels of PICF BALP and alveolar bone were measured. ISQ values significantly increased in smokers and non-smokers in the 3rd month (p < 0.05). ABL measurements were lower at 3 months compared to baseline in both groups (p < 0.05). Although ISQ and ABL values were higher in non-smokers than smokers at 3 months, the difference between the groups did not show any statistical significance. The PICF BALP levels in the 3rd month changed in both groups. But, these differences were insignificant. Although some of the measurements presented differences between the groups during the assessment periods, they were not indicative of the hazardous effects of smoking on bone healing around implants after surgery till functional loading in 3 months. However, smoking is an important factor to be considered for osseo-integration outcomes. Further studies are needed to clarify the influence of smoking on osseo-integration.

摘要

我们旨在研究吸烟者和非吸烟者在种植体负荷前 3 个月植入物周围龈沟液(PICF)中的种植体稳定性指数(ISQ)、牙槽骨水平测量(ABL)和骨碱性磷酸酶(BALP)。将 44 颗种植体等量植入吸烟者和非吸烟者患者中。在基线和手术后 3 个月测量 ISQ。测量 PICF BALP 和牙槽骨水平。ISQ 值在吸烟者和非吸烟者第 3 个月均显著增加(p < 0.05)。与基线相比,两组在第 3 个月的 ABL 测量值均较低(p < 0.05)。尽管在第 3 个月非吸烟者的 ISQ 和 ABL 值高于吸烟者,但两组之间的差异无统计学意义。PICF BALP 水平在两组中均在第 3 个月发生变化。但这些差异无统计学意义。尽管在评估期间,一些测量值在组间存在差异,但这些差异并不能表明吸烟对术后 3 个月功能负荷前种植体周围骨愈合的有害影响。然而,吸烟是影响骨整合结果的一个重要因素。需要进一步的研究来阐明吸烟对骨整合的影响。

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本文引用的文献

1
Clinical, radiological, and gene expression analyses in smokers and non-smokers, Part 2: RCT on the late healing phase of osseointegration.临床、影像学和基因表达分析在吸烟者和非吸烟者中的表现,第 2 部分:RCT 研究骨整合晚期愈合阶段。
Clin Implant Dent Relat Res. 2017 Oct;19(5):901-915. doi: 10.1111/cid.12514. Epub 2017 Jul 26.
2
Comparison between inflammation-related markers in peri-implant crevicular fluid and clinical parameters during osseointegration in edentulous jaws.在无牙颌骨骨整合过程中,种植体周围龈沟液中的炎症相关标志物与临床参数的比较。
Clin Oral Investig. 2018 Jan;22(1):531-543. doi: 10.1007/s00784-017-2169-0. Epub 2017 Jul 14.
3
Gene expression in peri-implant crevicular fluid of smokers and nonsmokers. 1. The early phase of osseointegration.
吸烟和非吸烟患者种植体周围龈沟液中的基因表达。1. 骨整合的早期阶段。
Clin Implant Dent Relat Res. 2017 Aug;19(4):681-693. doi: 10.1111/cid.12486. Epub 2017 May 3.
4
Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study.愈合期牙种植体稳定性与两种生物学标志物之间的关系:一项前瞻性临床研究。
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Genomic analyses of early peri-implant bone healing in humans: a systematic review.人类种植体周围早期骨愈合的基因组分析:一项系统综述。
Int J Implant Dent. 2015 Dec;1(1):5. doi: 10.1186/s40729-015-0006-2. Epub 2015 Mar 1.
6
Correlation of alkaline phosphatase activity to clinical parameters of inflammation in smokers suffering from chronic periodontitis.慢性牙周炎吸烟者碱性磷酸酶活性与炎症临床参数的相关性
J Indian Soc Periodontol. 2016 May-Jun;20(3):254-9. doi: 10.4103/0972-124X.183099.
7
Effect of Heavy Smoking on Dental Implants Placed in Male Patients Posterior Mandibles: A Prospective Clinical Study.重度吸烟对男性患者下颌后牙区种植牙的影响:一项前瞻性临床研究。
J Oral Implantol. 2016 Dec;42(6):477-483. doi: 10.1563/aaid-joi-D-16-00078. Epub 2016 Aug 19.
8
The impact of smoking on failure rates, postoperative infection and marginal bone loss of dental implants.吸烟对牙种植体失败率、术后感染及边缘骨丢失的影响。
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Factors Affecting Dental Implant Stability Measured Using the Ostell Mentor Device: A Systematic Review.使用奥斯特尔Mentor设备测量的影响牙种植体稳定性的因素:一项系统评价。
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