Liu Haixia, Pu Yudong, Ai Shiwei, Wang Xiaoxue, He Shuzhen, Wang Ke, Dang Yuhui
Institute of Maternal, Child and Adolescent Health, School of Public Health, Lanzhou University, Lanzhou, China.
Songshan Lake Central Hospital of Dongguan City, Dongguan, China.
Biol Trace Elem Res. 2022 Sep;200(9):3965-3974. doi: 10.1007/s12011-021-02988-5. Epub 2022 Jan 7.
Preeclampsia (PE) is a pregnancy-specific disorder, which is one of the leading causes of maternal, fetal, and neonatal death, particularly in developing countries. Arsenic (As), which is commonly found in soil and groundwater, has been associated with various complications of pregnancy, such as spontaneous abortion, hypertension, and stillbirth. Hence, the study was used to explore the relationship between PE and blood concentration of As in this study. Blood concentration of As during pregnancy was measured by inductively coupled plasma mass spectrometry (ICP-MS). The results shown that the mean blood concentration of As was gradually increased from the control group to the severe PE group (P < 0.0001). Elevated blood concentration of As was associated with the prevalence of PE (OR = 12.81, 95% CI: 2.43-67.39 and 27.55, 1.75-433.43 for middle and high vs. low). Furthermore, elevated blood concentration of As was associated with the severity of PE. Additionally, we observed that blood concentration of As was associated with the hypoproteinemia (P = 0.001, r = 0.37). Blood concentration of As was negatively corelated with the mean corpuscular volume (MCV) (P = 0.040, r = - 0.23) and positively corelated with the mean corpuscular hemoglobin concentration (MCHC) (P = 0.044, r = 0.23). Overall, our results indicated that the blood concentration of As can significantly predict the occurrence of PE. Additionally, we provided evidence that blood concentration of As may affect the occurrence of hypoproteinemia. These findings may provide some ideas for the prevention of PE and pregnancy complications.
子痫前期（PE）是一种妊娠特有的疾病，是孕产妇、胎儿和新生儿死亡的主要原因之一，在发展中国家尤为如此。常见于土壤和地下水中的砷（As）与妊娠的各种并发症有关，如自然流产、高血压和死产。因此，本研究旨在探讨PE与血液中As浓度之间的关系。采用电感耦合等离子体质谱法（ICP-MS）测定孕期血液中As的浓度。结果显示，从对照组到重度PE组，As的平均血液浓度逐渐升高（P < 0.0001）。血液中As浓度升高与PE的患病率相关（中、高浓度组与低浓度组相比，OR = 12.81，95% CI：2.43 - 67.39；以及OR = 27.55，95% CI：1.75 - 433.43）。此外，血液中As浓度升高与PE的严重程度相关。此外，我们观察到血液中As浓度与低蛋白血症相关（P = 0.001，r = 0.37）。血液中As浓度与平均红细胞体积（MCV）呈负相关（P = 0.040，r = -0.23），与平均红细胞血红蛋白浓度（MCHC）呈正相关（P = 0.044，r = 0.23）。总体而言，我们的结果表明，血液中As浓度可显著预测PE的发生。此外，我们提供的证据表明，血液中As浓度可能影响低蛋白血症的发生。这些发现可能为预防PE和妊娠并发症提供一些思路。
