Liu Xue-Mei, Liu Hui-Min, Ma Le-le, Zhang Ding-Kun, Ma Hong-Yan, Lin Jun-Zhi, Xu Run-Chun
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
Traditional Chinese Mdeicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610072, China.
Zhongguo Zhong Yao Za Zhi. 2021 Dec;46(24):6377-6386. doi: 10.19540/j.cnki.cjcmm.20210712.601.
Breast cancer is a major chronic disease threatening women's health. It has topped the global cancers as the diagnosed cases outnumbered lung cancer patients in 2020. Internal damage due to the seven emotions is an important cause of breast cancer and the disorders of hypothalamic-pituitary-adrenal(HPA) axis and endocrine system and the abnormal immune defense mechanism in response to psychological stress all affect the occurrence and development of breast cancer. It is noteworthy that the theory of seven emotions in traditional Chinese medicine and the psychological stress theory of modern medicine have something in common in some aspects. Therefore, this study explored the correlation between internal damage due to the seven emotions and psychological stress and analyzed the molecular biological mechanisms of psychological stress influencing breast cancer from the perspective of modern medicine, which is helpful to reasonably prevent breast cancer and other related tumors and improve the prognosis of breast cancer patients through emotion regulation.
乳腺癌是威胁女性健康的主要慢性疾病。它已成为全球头号癌症，2020年其确诊病例数超过肺癌患者。七情内伤是乳腺癌的重要病因，下丘脑 - 垂体 - 肾上腺（HPA）轴和内分泌系统紊乱以及心理应激反应中异常的免疫防御机制均影响乳腺癌的发生发展。值得注意的是，中医七情理论与现代医学心理应激理论在某些方面有共同之处。因此，本研究探讨了七情内伤与心理应激之间的相关性，并从现代医学角度分析了心理应激影响乳腺癌的分子生物学机制，这有助于通过情绪调节合理预防乳腺癌及其他相关肿瘤，并改善乳腺癌患者的预后。
