School of Chemistry and Chemical Engineering, the Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi City, 832004, China.
Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science & Technology, Wuhan City, 430074, China.
Org Biomol Chem. 2022 Jan 26;20(4):847-851. doi: 10.1039/d1ob02248b.
An efficient Pd-catalyzed direct C-H arylation of pyrrolo[1,2-]quinoxalines with aryl iodides is described, providing a selective route toward a series of 1-arylated and 1,3-diarylated pyrrolo[1,2-]quinoxalines in good yields. This method features a broad substrate scope, good functional group tolerance and gram-scale synthesis. Furthermore, the C3-thiocyanation of the arylated product is also achieved. We believe that these novel aryl-substituted pyrrolo [1,2-]quinoxalines will have a variety of applications in organic synthesis and medicinal chemistry.
一种高效的 Pd 催化的吡咯并[1,2-]喹喔啉与芳基碘化物的直接 C-H 芳基化反应被描述，为一系列 1-芳基和 1,3-二芳基吡咯并[1,2-]喹喔啉的合成提供了一条选择性途径，产率良好。该方法具有广泛的底物范围、良好的官能团耐受性和克级规模的合成。此外，还实现了芳基化产物的 C3-硫氰化反应。我们相信这些新型的芳基取代的吡咯并[1,2-]喹喔啉将在有机合成和药物化学中有多种应用。
