Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Laboratory of Veterinary Surgery, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
J Vet Intern Med. 2022 Mar;36(2):397-405. doi: 10.1111/jvim.16346. Epub 2022 Jan 7.
Information regarding changes in renin-angiotensin-aldosterone system (RAAS) during cardiac remodeling after mitral valvuloplasty (MVP) in dogs remains lacking.
HYPOTHESIS/OBJECTIVES: To assess the longitudinal effects of MVP on circulating RAAS activity.
Eight client-owned dogs receiving MVP for myxomatous mitral valve disease (MMVD).
This is a cohort study. Plasma renin activity (PRA), angiotensin II (AT2), aldosterone (PAC), blood urea nitrogen (BUN), and creatinine concentrations, were measured in these dogs before (baseline) and at 3 consecutive monthly follow-ups (Post-1M, Post-2M, Post-3M). Echocardiography was concomitantly used to assess the process of cardiac recovery after MVP.
The echocardiography revealed a significant decrease in LVIDDN, LA/Ao, FS, E velocity, E/A, E' sep, S' lat, E' lat, and A' lat after MVP compared with baseline (P < .05). There was a significant reduction in the PRA (2.45, 3.05, 2.74 vs 8.8 ng/mL/h; P = .002), AT2 (466, 315, 235 vs 1200 pg/mL; P = .009), and PAC (39.88, 47, 54.62 vs 179.5 pg/mL; P = .01), respectively at Post-1M, Post-2M, Post-3M compared to the baseline. Additionally, BUN and creatinine concentrations decreased from Post-1M. The RAAS variables showed significant, weak to moderate, relationship with selected echocardiographic variables.
Mitral valvuloplasty contributes to decreased RAAS activity in MMVD dogs, which paralleled the process of cardiac reverse remodeling up to Post-3M. This information facilitates formulating strategies to optimize clinical outcomes for dogs after MVP.
关于犬二尖瓣成形术后心脏重构过程中肾素-血管紧张素-醛固酮系统（RAAS）变化的信息仍然缺乏。
假设/目的：评估二尖瓣成形术（MVP）对循环 RAAS 活性的纵向影响。
8 只接受 MVP 治疗黏液样二尖瓣疾病（MMVD）的患犬。
这是一项队列研究。在 MVP 前（基线）和连续 3 次每月随访（术后 1 个月、术后 2 个月、术后 3 个月）时，测量这些犬的血浆肾素活性（PRA）、血管紧张素 II（AT2）、醛固酮（PAC）、血尿素氮（BUN）和肌酐浓度。同时进行超声心动图检查，以评估 MVP 后心脏恢复的过程。
超声心动图显示，与基线相比，MVP 后左室舒张末期内径（LVIDDN）、左心房/主动脉（LA/Ao）、射血分数（FS）、E 速度、E/A、E' 间隔、S' 间隔、E' 间隔和 A' 间隔显著降低（P <.05）。PRA（2.45、3.05、2.74 与 8.8 ng/mL/h；P =.002）、AT2（466、315、235 与 1200 pg/mL；P =.009）和 PAC（39.88、47、54.62 与 179.5 pg/mL；P =.01）分别在术后 1 个月、术后 2 个月和术后 3 个月时较基线显著降低。此外，BUN 和肌酐浓度从术后 1 个月开始下降。RAAS 变量与选定的超声心动图变量呈显著的、弱到中度的关系。
二尖瓣成形术导致 MMVD 犬 RAAS 活性降低，这与心脏反向重构过程相平行，直至术后 3 个月。这些信息有助于制定策略，优化 MVP 后犬的临床结果。
