Fujii Hideki, Nakamura Naotoshi, Fukumoto Shinya, Kimura Tatsuo, Nakano Akemi, Nadatani Yuji, Tauchi Yukie, Nishii Yuuko, Takashima Shingo, Kamada Yoshihiro, Watanabe Toshio, Kawada Norifumi
Department of Premier Preventive Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Interdisciplinary Biology Laboratory, Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan.
Liver Int. 2022 May;42(5):995-1004. doi: 10.1111/liv.15158. Epub 2022 Mar 18.
The coronavirus disease 2019 (COVID-19) pandemic precipitated lifestyle changes. We aimed to clarify whether COVID-19-induced lifestyle changes affected the development of metabolic dysfunction-associated fatty liver disease (MAFLD).
This retrospective longitudinal study included 973 participants who underwent health check-ups between 2018 and 2020. We used data from the MedCity21 health examination registry. Participants' clinical characteristics and lifestyle habits were investigated. Independent lifestyle predictors of MAFLD development before the pandemic (2018-2019) and during the pandemic (2019-2020) were identified using logistic regression analysis.
In 2018, 261 (27%) patients were diagnosed with MAFLD. Before the pandemic, 22 patients developed new MAFLD. During this time, routine late-night meals were identified as an independent lifestyle predictor of MAFLD development (hazard ratio [HR] 2.54, 95% confidence interval [CI] 1.02-6.36, P = .046). In contrast, 44 patients developed new MAFLD during the pandemic. During this time, higher daily alcohol intake was identified as an independent lifestyle predictor of MAFLD development (HR 1.03, 95% CI 1.01-1.05, P = .008). In participants aged <60 years, daily alcohol intake and the proportion of participants who ate 2 times/day were significantly higher in patients who developed MAFLD during the pandemic than in those who did not. In participants aged ≥60 years, no lifestyle habits were associated with MAFLD development before or during the pandemic.
New MAFLD diagnoses increased during the COVID-19 pandemic. Changes in lifestyle factors, particularly in those aged <60 years, must be monitored and addressed as the pandemic continues.
2019年冠状病毒病（COVID-19）大流行促使生活方式发生改变。我们旨在阐明COVID-19引起的生活方式改变是否影响代谢功能障碍相关脂肪性肝病（MAFLD）的发生发展。
这项回顾性纵向研究纳入了973名在2018年至2020年间接受健康检查的参与者。我们使用了MedCity21健康检查登记处的数据。对参与者的临床特征和生活习惯进行了调查。采用逻辑回归分析确定大流行前（2018 - 2019年）和大流行期间（2019 - 2020年）MAFLD发生发展的独立生活方式预测因素。
2018年，261名（27%）患者被诊断为MAFLD。大流行前，22名患者出现新发MAFLD。在此期间，经常吃夜宵被确定为MAFLD发生发展的独立生活方式预测因素（风险比[HR] 2.54，95%置信区间[CI] 1.02 - 6.36，P = 0.046）。相比之下，大流行期间有44名患者出现新发MAFLD。在此期间，每日酒精摄入量较高被确定为MAFLD发生发展的独立生活方式预测因素（HR 1.03，95% CI 1.01 - 1.05，P = 0.008）。在年龄<60岁的参与者中，大流行期间发生MAFLD的患者每日酒精摄入量和每天进食2次的参与者比例显著高于未发生MAFLD的患者。在年龄≥60岁的参与者中，大流行前或大流行期间没有生活习惯与MAFLD的发生发展相关。
COVID-19大流行期间新发MAFLD诊断增加随着大流行的持续，必须监测并解决生活方式因素的变化，尤其是在年龄<60岁的人群中。
