Department of Advanced Metabolic Hepatology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Liver Center, Saga University Hospital, Faculty of Medicine, Saga University, Saga 840-8502, Japan.
Nutrients. 2022 Aug 23;14(17):3453. doi: 10.3390/nu14173453.
Weight loss improves the liver pathophysiological status of nonalcoholic fatty liver disease (NAFLD) patients. However, there are few studies that investigate the accurate relationships between nutritional intake and disease progression in NAFLD patients. A total of 37 biopsy-confirmed NAFLD patients were enrolled in this study. Clinical and nutritional control data of 5074 persons were obtained from the National Institute of Health and Nutrition. Each NAFLD subject recorded dietary intake for seven consecutive days using a dietary questionnaire and photographs of each meal. A dietitian analyzed and quantified the nutritional data in each patient. We further analyzed the nutritional intake of NAFLD patients in three groups according to the following criteria: (1) liver fibrosis degree (advanced, early), (2) gender (male, female), and (3) body mass index (BMI) (high, low). Excesses or deficiencies of multiple nutrients were found in NAFLD patients compared with control subjects. In addition, there were variations in nutritional intake. (1) The intake of vitamins A, B, and E, pantothenic acid, soluble dietary fiber, and salt was lower in the advanced fibrosis group than in the early fibrosis group. (2) Fat intake was higher in male patients, and dietary fiber intake was lower in both male and female patients compared with control subjects. (3) Saturated fatty acid intake was higher, and copper and vitamin E intakes were lower in patients with high BMI than with low BMI. Our study demonstrates that differences were found in some nutrient intake of NAFLD patients and controls and according to the severity of the conditions (liver fibrosis degree, BMI).
体重减轻可改善非酒精性脂肪性肝病（NAFLD）患者的肝脏病理生理状态。然而，很少有研究调查 NAFLD 患者的营养摄入与疾病进展之间的准确关系。本研究共纳入 37 例经肝活检证实的 NAFLD 患者。从国立健康与营养研究所获得了 5074 名个体的临床和营养控制数据。每位 NAFLD 患者使用饮食问卷和每餐照片记录连续 7 天的饮食摄入。营养师对每位患者的营养数据进行了分析和量化。我们根据以下标准进一步分析了 NAFLD 患者的营养摄入：（1）肝纤维化程度（晚期，早期），（2）性别（男，女），和（3）体重指数（BMI）（高，低）。与对照组相比，NAFLD 患者存在多种营养素的过量或不足。此外，营养摄入也存在差异。（1）与早期纤维化组相比，晚期纤维化组的维生素 A、B、E、泛酸、可溶性膳食纤维和盐的摄入量较低。（2）与对照组相比，男性患者的脂肪摄入量较高，男性和女性患者的膳食纤维摄入量均较低。（3）与低 BMI 患者相比，高 BMI 患者的饱和脂肪酸摄入量较高，铜和维生素 E 的摄入量较低。我们的研究表明，NAFLD 患者和对照组之间以及根据病情严重程度（肝纤维化程度、BMI）存在一些营养素摄入的差异。
