Bouroncle B A, Grever M R, Kraut E H
Ohio State University, Department of Medicine, Columbus.
Leukemia. 1987 Apr;1(4):350-4.
Twelve evaluable patients with progressive hairy cell leukemia were treated with deoxycoformycin at a dose of 4 mg/m2 every 2 weeks. Five patients had not been splenectomized, and one had failed to respond to interferon-alpha. Complete remission, as defined by absence of hairy cells in the bone marrow and normalization of the peripheral blood and regression of splenomegaly, was obtained in 11 of 12 patients (92%). These patients have remained in unmaintained remission for 1+ to 13 months with an average of 7.5 months. Two of these patients had a bone marrow relapse at 8 and 12 months, respectively. During treatment the monocytopenia corrected, and, after complete remission was obtained, marrow was aspirable. Toxicity was mild and reversible. There were no significant infections associated with this treatment. It was of interest that we could treat two patients with creatinine clearance of 50 and 60 ml/min using lower doses (and 2-3 mg/m2) than our conventional therapy of 4 mg/m2 every 2 weeks. They obtained a complete remission after 6 and 10 treatments, respectively. Low-dose deoxycoformycin has proven to be an excellent treatment for hairy cell leukemia.
12例可评估的进展性毛细胞白血病患者接受了脱氧助间型霉素治疗，剂量为每2周4mg/m²。5例患者未行脾切除术，1例对α-干扰素治疗无效。按照骨髓中无毛细胞、外周血正常化及脾肿大消退来定义，12例患者中有11例（92%）获得完全缓解。这些患者未接受维持治疗而持续缓解1个月以上至13个月，平均7.5个月。其中2例患者分别在第8个月和第12个月出现骨髓复发。治疗期间单核细胞减少症得到纠正，完全缓解后骨髓可进行穿刺。毒性轻微且可逆。该治疗未出现明显感染。有趣的是，对于2例肌酐清除率分别为50和60ml/min的患者，我们使用了低于常规治疗每2周4mg/m²的剂量（2-3mg/m²）进行治疗。他们分别在接受6次和10次治疗后获得完全缓解。低剂量脱氧助间型霉素已被证明是治疗毛细胞白血病的一种优秀疗法。
