Bartha E, Szelényi J, Szilágyi K, Venter V, Thu Ha N T, Páldi-Haris P, Hollán S
National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Neurosci Lett. 1987 Aug 18;79(1-2):190-4. doi: 10.1016/0304-3940(87)90695-1.
Reductions in the acetylcholinesterase (AChE) activity of certain brain areas in patients with senile dementia of Alzheimer type (SDAT) have been found to correlate with the severity of the disease, suggesting a central cholinergic lesion. Since AChE is expressed on the surface of various blood cells too, the AChE activity of lymphocytes and erythrocytes was determined to test the possibility whether the cholinergic lesion is also reflected on these readily available cells. The AChE activity of lymphocytes in SDAT and in alcoholic dementia (AD) were significantly lower as compared to those of the age-matched healthy volunteers. In contrast, there was no significant difference in the activity of lymphocyte AChE between age-matched healthy controls and patients with multi-infarct dementia of vascular origin (MID). No changes could be demonstrated in the erythrocyte AChE activities of the patients studied, and the age-matched healthy individuals, when comparing them to the healthy blood donors. The AChE activity of lymphocytes may thus be a useful marker to follow the alterations in the metabolism of acetylcholine (ACh) in the central nervous system (CNS) of different types of dementia.
已发现，阿尔茨海默型老年痴呆症（SDAT）患者某些脑区的乙酰胆碱酯酶（AChE）活性降低与疾病严重程度相关，提示存在中枢胆碱能损伤。由于AChE也在各种血细胞表面表达，因此测定淋巴细胞和红细胞的AChE活性，以检验胆碱能损伤是否也反映在这些易于获取的细胞上。与年龄匹配的健康志愿者相比，SDAT患者和酒精性痴呆（AD）患者的淋巴细胞AChE活性显著降低。相比之下，年龄匹配的健康对照与血管性多梗死性痴呆（MID）患者之间，淋巴细胞AChE活性无显著差异。在将所研究患者及年龄匹配的健康个体的红细胞AChE活性与健康献血者进行比较时，未发现有变化。因此，淋巴细胞的AChE活性可能是追踪不同类型痴呆患者中枢神经系统（CNS）中乙酰胆碱（ACh）代谢变化的有用标志物。
