Colorado School of Public Health, Anschutz Medical Campus, Aurora, Colorado.
Children's Hospital Colorado, Anschutz Medical Campus, Aurora, Colorado.
Am J Trop Med Hyg. 2022 Jan 7;106(2):562-565. doi: 10.4269/ajtmh.21-1036.
The dried-tube specimen (DTS) procedure was used to develop the COVID-19 serology control panel (CSCP). The DTS offers the benefit of shipping materials without a cold chain, allowing for greater access without deterioration of material integrity. Samples in the panel were sourced from COVID-19 convalescent persons from March to May 2020. The immunoglobulin subtypes (total Ig, IgM, and IgG) and their respective reactivity to severe acute respiratory syndrome coronavirus 2 nucleocapsid, spike, and receptor-binding domain antigens of the samples were delineated and compared with the WHO International Standard to elucidate the exact binding antibody units of each CSCP sample and ensure the CSCP provides adequate reactivity for different types of serological test platforms. We distribute the CSCP as a kit with five coded tubes to laboratories around the world to be used to compare test kits for external quality assurance, for harmonizing laboratory testing, and for use as training materials for laboratory workers.
干管标本（DTS）程序用于开发 COVID-19 血清学控制面板（CSCP）。DTS 具有无需冷链运输材料的优势，允许在不降低材料完整性的情况下更方便地获取。面板中的样本来自 2020 年 3 月至 5 月的 COVID-19 康复者。免疫球蛋白亚型（总 Ig、IgM 和 IgG）及其对严重急性呼吸综合征冠状病毒 2 核衣壳、刺突和受体结合域抗原的反应性被描绘出来，并与世界卫生组织国际标准进行了比较，以阐明每个 CSCP 样本的确切结合抗体单位，并确保 CSCP 为不同类型的血清学测试平台提供足够的反应性。我们将 CSCP 作为一个带有五个编码管的试剂盒分发给世界各地的实验室，用于比较试剂盒的外部质量保证、协调实验室测试以及作为实验室工作人员的培训材料。
