Instituto de Pesquisa Clínica Carlos Borborema, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil.
Instituto Leônidas & Maria Deane, Fundação Oswaldo Cruz, Manaus, Brazil.
Am J Trop Med Hyg. 2022 Jan 7;106(2):571-573. doi: 10.4269/ajtmh.21-1009.
Between April and July 2020, and, therefore, prior to the broad recommendation of corticosteroids for severe COVID-19, a total of 50 full autopsies were performed in Manaus. We confirmed two invasive cases of aspergillosis through histopathology and gene sequencing (4%) in our autopsy series. The confirmed invasive aspergillosis incidence seems much lower than expected based on the "probable and possible" definitions, and an individualized approach should be considered for each country scenario. Interestingly, a prolonged length of stay in the intensive care unit was not observed in any of the cases. Timely diagnosis and treatment of fungal infection can reduce mortality rates.
2020 年 4 月至 7 月期间，即在广泛推荐皮质类固醇治疗重症 COVID-19 之前，我们在马瑙斯总共进行了 50 例全尸解剖。我们通过组织病理学和基因测序在尸检系列中确认了两例侵袭性曲霉菌病（4%）。基于“可能”和“很可能”的定义，确认的侵袭性曲霉菌病发病率似乎远低于预期，每个国家的情况都应考虑采取个体化方法。有趣的是，我们没有在任何病例中观察到重症监护病房住院时间延长。及时诊断和治疗真菌感染可以降低死亡率。
