Department of Obstetrics and Gynecology, Changchun Obstetrics-Gynecology Hospital, Changchun, China.
Department of Obstetrics, The First Hospital of Jilin University, Changchun, China.
J Obstet Gynaecol. 2022 Jul;42(5):1132-1136. doi: 10.1080/01443615.2021.2012438. Epub 2022 Jan 7.
A case-control study was designed to investigate the association between the angiotensin converting enzyme 2 (ACE2) rs879922, glucose-6-phosphate dehydrogenase (G6PD) rs1050828, and tenomodulin (TNMD) rs4828038 single nucleotide polymorphisms (SNPs), and preeclampsia. A total of 356 Han Chinese pregnant women (170 controls and 186 cases) were recruited into the study. ACE2 rs879922, G6PD rs1050828, and TNMD rs4828038 were tested by the targeted next-generation sequencing technology and the data were analyzed using SPSS version 18. Genotyping of results revealed that patients with the CC/CT genotype in SNP rs4828038 or CC/CG genotype in SNP rs879922 had a significantly decreased susceptibility to late-onset preeclampsia (CC/CT versus TT: OR = 0.543, 95% CI = 0.378 to 0.779, = .001; CC/CG versus GG: OR = 0.510, 95% CI = 0.038 to 0.860, = .012). Our study found that the polymorphisms TNMD rs4828038 and ACE2 rs879922 might be associated with late-onset preeclampsia.IMPACT STATEMENT Preeclampsia is associated with multiple SNPs, and ACE2 rs879922, G6PD rs1050828, and TNMD rs4828038 are related to essential hypertension and glucose and lipid metabolism disorders. Essential hypertension, diabetes, and dyslipidemia are risks for preeclampsia. The associations between those three SNPs and preeclampsia have not been reported. The polymorphisms of TNMD rs4828038 and ACE2 rs879922 might be associated with the risk of late-onset preeclampsia. There was no relationship between SNP rs1050828 and preeclampsia. TNMD rs4828038 and ACE2 rs879922 might be target sites for genetic diagnosis and therapy, and the levels of mRNA and protein in pregnant women with preeclampsia should be further tested.
一项病例对照研究旨在探讨血管紧张素转换酶 2（ACE2）rs879922、葡萄糖-6-磷酸脱氢酶（G6PD）rs1050828 和腱调蛋白（TNMD）rs4828038 单核苷酸多态性（SNP）与子痫前期之间的关联。共招募了 356 名汉族孕妇（170 名对照和 186 名病例）参与研究。采用靶向下一代测序技术检测 ACE2 rs879922、G6PD rs1050828 和 TNMD rs4828038，并使用 SPSS 18 版本进行数据分析。结果显示，SNP rs4828038 的 CC/CT 基因型或 SNP rs879922 的 CC/CG 基因型的患者发生晚发型子痫前期的易感性显著降低（CC/CT 与 TT：OR = 0.543，95%CI = 0.378 至 0.779， =.001；CC/CG 与 GG：OR = 0.510，95%CI = 0.038 至 0.860， =.012）。我们的研究发现，TNMD rs4828038 和 ACE2 rs879922 多态性可能与晚发型子痫前期有关。
意义陈述：子痫前期与多个 SNP 有关，ACE2 rs879922、G6PD rs1050828 和 TNMD rs4828038 与原发性高血压和糖脂代谢紊乱有关。原发性高血压、糖尿病和血脂异常是子痫前期的危险因素。这三个 SNP 与子痫前期的关联尚未报道。TNMD rs4828038 和 ACE2 rs879922 多态性可能与晚发型子痫前期的风险相关。SNP rs1050828 与子痫前期无关。TNMD rs4828038 和 ACE2 rs879922 可能是遗传诊断和治疗的靶点，应进一步检测子痫前期孕妇的 mRNA 和蛋白水平。
