血液中晚期氧化蛋白产物水平与亚临床动脉粥样硬化相关。
Level of advanced oxidation protein products is associated with subclinical atherosclerosis.
机构信息
Heart and Vascular Center, Semmelweis University, Városmajor utca 68, Budapest, 1122, Hungary.
Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad tér 4, Budapest, 1089, Hungary.
出版信息
BMC Cardiovasc Disord. 2022 Jan 8;22(1):5. doi: 10.1186/s12872-021-02451-2.
BACKGROUND
Oxidative stress is an important factor in the pathomechanism of atherosclerosis. Advanced oxidation protein products (AOPPs) are considered markers of oxidative stress. Thickening of the carotid intima-media layers indicates subclinical atherosclerosis and can be detected by carotid ultrasound.
OBJECTIVE
Our aim was to examine the association between carotid intima-media thickness (CIMT) and the level of AOPPs.
METHODS
Carotid duplex scans and measurements of AOPPs were performed on 476 participants of a cardiovascular population study. The presence of conventional cardiovascular risk factors was investigated with a questionnaire, physical examination, and laboratory tests.
RESULTS
There was a positive correlation between maximum CIMT and the level of AOPPs only in the male population (r = 0.219, p = 0.033). Multivariate analysis has revealed that the association between AOPPs and mean or maximum CIMT was independent of cardiovascular risk factors (OR = 1.458, p = 0.004, and OR = 2.038, p < 0.001).
CONCLUSIONS
Among males, the elevated level of AOPPs as a marker of oxidative stress may signal the existence of early atherosclerotic alterations.
背景
氧化应激是动脉粥样硬化发病机制中的一个重要因素。氧化应激蛋白产物（AOPPs）被认为是氧化应激的标志物。颈动脉内膜中层厚度（CIMT）的增厚表明亚临床动脉粥样硬化，可以通过颈动脉超声检测到。
目的
本研究旨在探讨颈动脉内膜中层厚度（CIMT）与 AOPPs 水平之间的关系。
方法
对心血管人群研究的 476 名参与者进行颈动脉双功能超声扫描和 AOPPs 测量。通过问卷调查、体格检查和实验室检查来调查传统心血管危险因素的存在情况。
结果
仅在男性人群中，最大 CIMT 与 AOPPs 水平之间存在正相关（r=0.219，p=0.033）。多变量分析显示，AOPPs 与平均或最大 CIMT 之间的关联独立于心血管危险因素（OR=1.458，p=0.004 和 OR=2.038，p<0.001）。
结论
在男性中，AOPPs 作为氧化应激的标志物水平升高可能表明存在早期动脉粥样硬化改变。
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