Yildiz Gürsel, Duman Alptekin, Aydin Hüseyin, Yilmaz Abdulkerim, Hür Ender, Mağden Kemal, Cetin Gülay, Candan Ferhan
Department of Internal Medicine and Nephrology, Atatürk State Hospital, Zonguldak, Turkey.
Hemodial Int. 2013 Jul;17(3):397-405. doi: 10.1111/hdi.12041. Epub 2013 Apr 1.
Incidence of cardiovascular diseases in the patients having chronic kidney disease (CKD) is between 25% and 60%. This increased rate is proposed to be associated with "accelerated atherosclerosis." Increased carotid intima-media thickness (CIMT) is a subclinical atherosclerosis marker. Small-dense low-density lipoprotein particles are a strong risk factor for atherosclerosis. It was shown that atherogenic index of plasma (AIP = log(TG/HDL-c)) is correlated with size of the lipoprotein particles. We investigated the correlation between AIP and CIMT which is a subclinical atherosclerosis marker, in hemodialysis (HD) patients. A total of 62 persons with 31 patients under HD therapy and 31 volunteers were included in the study. In all the participants, CIMT was measured and AIP were calculated. AIP and CIMT values of the participants were compared with blood pressures, lipid profiles and the other risk factors. AIP (0.39 ± 0.32) and CIMT (0.57 ± 0.13) were found significantly higher in the patient group than in the controls (0.04 ± 0.36 and 0.45 ± 0.119, respectively); (P = 0.0001 and 0.0001, respectively). There was a significant correlation between AIP and increased CIMT in the patient group (P = 0.0001, r = 0.430). Among the lipid parameters, the strongest correlation was found between CIMT and AIP. We demonstrated the significant increase of AIP and CIMT in HD patients. A correlation was found between AIP and CIMT. AIP was found to show a correlation with a greater number of risk factors, both classical and CKD specific, than CIMT. These data suggest that AIP might be a method which can be used both in diagnosis of subclinical atherosclerosis and in deceleration processes of its progression.
慢性肾脏病（CKD）患者心血管疾病的发病率在25%至60%之间。这种升高的发病率被认为与“加速动脉粥样硬化”有关。颈动脉内膜中层厚度（CIMT）增加是亚临床动脉粥样硬化的一个标志物。小而致密的低密度脂蛋白颗粒是动脉粥样硬化的一个强风险因素。研究表明，血浆致动脉粥样硬化指数（AIP = log（TG/HDL-c））与脂蛋白颗粒大小相关。我们研究了血液透析（HD）患者中作为亚临床动脉粥样硬化标志物的AIP与CIMT之间的相关性。该研究共纳入62人，其中31例接受HD治疗的患者和31名志愿者。对所有参与者测量了CIMT并计算了AIP。将参与者的AIP和CIMT值与血压、血脂谱及其他风险因素进行比较。发现患者组的AIP（0.39±0.32）和CIMT（0.57±0.13）显著高于对照组（分别为0.04±0.36和0.45±0.119）；（P值分别为0.0001和0.0001）。患者组中AIP与CIMT增加之间存在显著相关性（P = 0.0001，r = 0.430）。在血脂参数中，CIMT与AIP之间的相关性最强。我们证明了HD患者中AIP和CIMT显著升高。发现AIP与CIMT之间存在相关性。与CIMT相比，发现AIP与更多经典和CKD特异性风险因素相关。这些数据表明，AIP可能是一种可用于亚临床动脉粥样硬化诊断及其进展减速过程的方法。
