Histopathology Department, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK
Healthy Lifespan and Neuroscience Institute, Department of Biosciences, The University of Sheffield, Sheffield, UK.
J Clin Pathol. 2022 Jun;75(6):361-364. doi: 10.1136/jclinpath-2021-208073. Epub 2022 Jan 7.
NKX3.1 is a multifaceted protein with roles in prostate development and protection from oxidative stress. Acting as a pioneer factor, NKX3.1 interacts with chromatin at enhancers to help integrate androgen regulated signalling. In prostate cancer, NKX3.1 activity is frequently reduced through a combination of mutational and post-translational events. Owing to its specificity for prostate tissue, NKX3.1 has found use as an immunohistochemical marker in routine histopathology practice.
NKX3.1 是一种具有多方面功能的蛋白质，在前列腺发育和抵抗氧化应激方面发挥作用。作为一种先驱因子，NKX3.1 与增强子处的染色质相互作用，帮助整合雄激素调节的信号。在前列腺癌中，NKX3.1 的活性经常通过突变和翻译后事件的组合而降低。由于其对前列腺组织的特异性，NKX3.1 已被用作常规组织病理学实践中的免疫组织化学标志物。
