Department of Pediatrics, Xiangya Hospital, Central South University, Xiangya Road, Changsha City, 410008, Hunan Province, People's Republic of China.
Department of Pediatric, The First Hospital of Changsha, Changsha, Hunan, China.
Sci Rep. 2022 Jan 7;12(1):208. doi: 10.1038/s41598-021-03099-w.
There is limited research into Invasive fungal disease (IFD) in children with no underlying disease. We undertook a retrospective study of children with IFD who did not suffer from another underlying disease, from June 2010 to March 2018 in Changsha, China. Nine children were identified. Eosinophil counts were elevated in six cases. The level of procalcitonin (PCT) was elevated in six cases. Fungal culture was positive in all patients, including eight cases of Cryptococcus neoformans and one case of Candida parapsilosis. 8.33 days following antifungal treatment, the body temperature of the eight patients affected by cryptococcal disease had returned to normal. Our study indicates that the primary pathogen in IFD was Cryptococcus neoformans in children who had no other underlying disease. Eosinophils can be considered to be indicators of cryptococcal infection. IFD in children with no other underlying disease has a satisfactory prognosis.
在中国长沙，我们对 2010 年 6 月至 2018 年 3 月期间无其他基础疾病的 IFD 患儿进行了一项回顾性研究，该研究纳入了 9 例 IFD 患儿。其中 6 例患儿的嗜酸性粒细胞计数升高，6 例患儿降钙素原（PCT）水平升高。所有患者的真菌培养均为阳性，包括 8 例新型隐球菌和 1 例近平滑假丝酵母菌。接受抗真菌治疗 8.33 天后，8 例新型隐球菌病患儿的体温恢复正常。本研究表明，无其他基础疾病的 IFD 患儿的主要病原体为新型隐球菌。嗜酸性粒细胞可作为隐球菌感染的指标。无其他基础疾病的 IFD 患儿的预后良好。
