King Jill, Pana Zoi-Dorothea, Lehrnbecher Thomas, Steinbach William J, Warris Adilia
Aberdeen Fungal Group, Medical Research Council Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, and the Royal Aberdeen Children's Hospital, United Kingdom.
Hospital Epidemiology and Infection Control, Division of Infectious Diseases, Johns Hopkins Hospital, Baltimore, Maryland.
J Pediatric Infect Dis Soc. 2017 Sep 1;6(suppl_1):S12-S21. doi: 10.1093/jpids/pix053.
Invasive fungal diseases (IFDs) are devastating opportunistic infections that result in significant morbidity and death in a broad range of pediatric patients, particularly those with a compromised immune system. Recognizing them can be difficult, because nonspecific clinical signs and symptoms or isolated fever are frequently the only presenting features. Therefore, a high index of clinical suspicion is necessary in patients at increased risk of IFD, which requires knowledge of the pediatric patient population at risk, additional predisposing factors within this population, and the clinical signs and symptoms of IFD. With this review, we aim to summarize current knowledge regarding the recognition and clinical presentation of IFD in neonates and children.
侵袭性真菌病（IFD）是一种具有毁灭性的机会性感染，在广泛的儿科患者中，尤其是免疫系统受损的患者中，会导致严重的发病和死亡。识别这些疾病可能很困难，因为非特异性的临床体征和症状或单纯发热常常是唯一的表现特征。因此，对于IFD风险增加的患者，必须保持高度的临床怀疑，这需要了解有风险的儿科患者群体、该群体中的其他易感因素以及IFD的临床体征和症状。通过本综述，我们旨在总结目前关于新生儿和儿童IFD的识别和临床表现的知识。
