Department of Traditional Chinese Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 200233 Shanghai, China.
Department of Encephalopathy, Shanghai Municipal Hospital of Traditional Chinese Medicine, 200071 Shanghai, China.
J Integr Neurosci. 2021 Dec 30;20(4):1001-1010. doi: 10.31083/j.jin2004101.
Alzheimer's disease typically presents with impaired cognition and pathological morphologic changes, including the accumulation of amyloid-β plaques. Disease-modifying drugs are in urgent need as neuroprotective therapies. Exploration of novel therapeutics for alleviating symptoms of Alzheimer's disease has found promise in plant extracts of functional phenols. Paeonol is a water-soluble phenolic substance that has been shown to confer diverse biological effects, including neuroprotection. An Alzheimer's disease model of APP/PS1 double transgenic mice was used in this study, and the therapeutic effects of paeonol were assessed after three weeks' administration. It was found that paeonol treatment significantly increased behavioral performance in the Morris water maze test and increased discrimination rate in the novel object recognition test compared to vehicle-treated APP/PS1 mice. Histologically, paeonol treatment significantly alleviated the Aβ plaque burden, reduced neural loss, inhibited microglia activation, and decreased neuroinflammation in the brain of APP/PS1 mice. In addition, a number of Alzheimer's disease-related synaptic plasticity deficits were ameliorated. The present results indicate that paeonol significantly relieved amyloid-β deposition and amyloid-β -mediated neuropathology in the brain of APP/PS1 mice, suggesting the potential of paeonol as a preventive and therapeutic agent for Alzheimer's disease.
阿尔茨海默病通常表现为认知障碍和病理性形态改变，包括淀粉样β斑块的积累。由于神经保护疗法的需要，目前急需开发疾病修饰药物。探索用于缓解阿尔茨海默病症状的新型治疗方法，在具有功能酚类的植物提取物中发现了希望。丹皮酚是一种水溶性酚类物质，已被证明具有多种生物学效应，包括神经保护作用。本研究采用 APP/PS1 双转基因小鼠阿尔茨海默病模型，评估丹皮酚给药 3 周后的治疗效果。结果发现，与 vehicle 处理的 APP/PS1 小鼠相比，丹皮酚治疗显著提高了 Morris 水迷宫测试中的行为表现，并提高了新物体识别测试中的辨别率。组织学上，丹皮酚治疗显著减轻了 Aβ 斑块负担，减少了神经丢失，抑制了小胶质细胞激活，并降低了 APP/PS1 小鼠大脑中的神经炎症。此外，还改善了一些与阿尔茨海默病相关的突触可塑性缺陷。这些结果表明，丹皮酚显著缓解了 APP/PS1 小鼠大脑中的淀粉样β沉积和淀粉样β介导的神经病理学，表明丹皮酚作为阿尔茨海默病预防和治疗药物的潜力。
