Hayes W S, Sherman J L, Stern B J, Citrin C M, Pulaski P D
Department of Radiology, Georgetown University Hospital, Washington, DC 20007.
AJR Am J Roentgenol. 1987 Nov;149(5):1043-9. doi: 10.2214/ajr.149.5.1043.
Fourteen patients with CNS manifestations of neurosarcoidosis were evaluated by MR imaging and CT. Evaluations were done on a 0.5-T superconductive magnet with T1- and T2-weighted sequences. CT with contrast was obtained in all patients. The granulomatous lesions were classified by location into basilar, convexity, intrahemispheric, and periventricular white-matter involvement. Hydrocephalus with or without an associated lesion was also noted. MR determined the presence of disease in all patients (100%), but was less accurate than CT in depicting disease in two patients (14%). CT determined the presence of disease in 12 patients (85%) and was less accurate than MR in delineating hypothalamic involvement in two patients and periventricular white-matter disease in three patients. There was great variability in the appearance of intracranial sarcoidosis on MR. Three patients had lesions that were isointense or hypointense (relative to cerebral cortex) on both T1- and T2-weighted images while nine patients had lesions that were hyperintense on T2-weighted images. Convexity involvement and hydrocephalus were well documented by both CT and MR. These results indicate that both MR and CT are helpful in fully evaluating a patient with suspected intracranial sarcoidosis.
对14例有神经结节病中枢神经系统表现的患者进行了磁共振成像（MR）和计算机断层扫描（CT）评估。评估在一台0.5-T超导磁体上进行，采用T1加权和T2加权序列。所有患者均进行了增强CT检查。肉芽肿性病变根据位置分为基底节、脑凸面、脑半球内和脑室周围白质受累。还记录了有无相关病变的脑积水情况。MR能确定所有患者（100%）存在疾病，但在描绘2例患者（14%）的疾病时不如CT准确。CT确定12例患者（85%）存在疾病，在描绘2例患者的下丘脑受累和3例患者的脑室周围白质病变时不如MR准确。颅内结节病在MR上的表现差异很大。3例患者的病变在T1加权和T2加权图像上均与脑皮质等信号或低信号，而9例患者的病变在T2加权图像上为高信号。CT和MR均能很好地记录脑凸面受累和脑积水情况。这些结果表明，MR和CT在全面评估疑似颅内结节病患者时均有帮助。
