Rivero-Yeverino Daniela, López-García Aída Inés, Caballero-López Chrystopherson Gengyny, Ríos-López Juan Jesús, Papaqui-Tapia José Sergio, Ortega-Jordá Rodríguez Elisa Elisa, Álvarez-Rivera Armando, Ruiz-Sánchez Dulce Mariel, Flores-Gonzaga Edgar
Benemérita Universidad Autónoma de Puebla, Hospital Universitario de Puebla, Servicio de Alergología e Inmunología Clínica, Puebla, Puebla, México.
Rev Alerg Mex. 2022;69 Suppl 1:s46-s54. doi: 10.29262/ram.v69iSupl1.1033.
An increasing number of studies are analyzing the relationship between serum vitamin D levels and the development of sensitization and allergic diseases in genetically predisposed individuals, as well as the impact of vitamin D supplementation. This article reviews the literature on this subject. Clinical trials, meta-analyses and systematic reviews consulted in PubMed, EMBASE, Scopus, Ovid, Wiley Online Library, Springer, Cochrane and manual resources were included, with the keywords: vitamin D, 25 hydroxyvitamin D, cholecalciferol, asthma, rhinitis, allergy, 25-OH-D, 1,25 hydroxyvitamin D, supplementation. The results show a positive linear trend, however, differ. We should keep in mind that in the studies there is heterogeneity of population groups and associated factors, which may modify such studies. It is necessary to increase research to clarify this relationship and to have successful interventions from the patient's approach to the strengthening of pharmacological and immunological treatment of allergic patients with these diseases.
越来越多的研究正在分析血清维生素D水平与遗传易感性个体中致敏和过敏性疾病发展之间的关系，以及维生素D补充剂的影响。本文综述了关于该主题的文献。纳入了在PubMed、EMBASE、Scopus、Ovid、Wiley Online Library、Springer、Cochrane以及手工检索资源中查阅到的临床试验、荟萃分析和系统评价，关键词为：维生素D、25-羟基维生素D、胆钙化醇、哮喘、鼻炎、过敏、25-OH-D、1,25-二羟基维生素D、补充剂。结果显示出正线性趋势，然而，结果存在差异。我们应该记住，在这些研究中人群组和相关因素存在异质性，这可能会改变此类研究。有必要增加研究以阐明这种关系，并从患者角度成功进行干预，以加强对患有这些疾病的过敏患者的药物和免疫治疗。
