Service de gastroentérologie et d'hépatologie du Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud, Switzerland; Institute of Liver Studies, King's College Hospital, London, United Kingdom.
Service de gastroentérologie et d'hépatologie du Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Vaud, Switzerland.
Clin Res Hepatol Gastroenterol. 2022 Apr;46(4):101858. doi: 10.1016/j.clinre.2022.101858. Epub 2022 Jan 7.
Transjugular intrahepatic portosystemic shunt (TIPS) is nowadays the benchmark treatment of severe portal hypertension complications. However, besides usual contraindication to the procedure (namely recurrent hepatic encephalopathy, severe liver dysfunction, right heart failure and/or pulmonary hypertension), TIPS appears regularly unfeasible due to abnormal and/or distorted anatomy. In this situation, the only non-surgical approaches to treat severe portal hypertension consist in the creation of an intrahepatic portocaval shunt from percutaneous (direct intrahepatic portocaval shunt - DIPS) or transjugular route (transjugular transcaval intrahepatic portosystemic shunt - TTIPS). These procedures have been rapidly adopted in patients with Budd-Chiari syndrome but are only poorly reported in patients with cirrhosis and without BCS. Considering the broadening landscape of TIPS indication in patients with cirrhosis within the last ten years, we aimed to describe the techniques, safety and efficacy of DIPS and TTIPS procedures as an alternative to TIPS in case of unfavourable anatomy.
经颈静脉肝内门体分流术(TIPS)目前是治疗严重门静脉高压并发症的基准疗法。然而,除了该手术的常见禁忌证(即复发性肝性脑病、严重肝功能障碍、右心衰竭和/或肺动脉高压)外,由于异常和/或变形的解剖结构,TIPS 通常也不可行。在这种情况下,治疗严重门静脉高压的唯一非手术方法是经皮(直接经肝内门体分流术-DIPS)或经颈静脉途径(经颈静脉经腔静脉肝内门体分流术-TTIPS)创建肝内门腔分流术。这些操作已在布加综合征患者中迅速采用,但在肝硬化且无布加综合征的患者中报道较少。考虑到在过去十年中肝硬化患者 TIPS 适应证的范围不断扩大,我们旨在描述 DIPS 和 TTIPS 作为 TIPS 替代方法在不利解剖结构情况下的技术、安全性和疗效。