离子载体A23187存在下豚鼠离体胃的胃酸分泌及环核苷酸含量
Acid secretion and cyclic nucleotide content of the guinea pig isolated stomach in the presence of the ionophore A23187.
作者信息
Canfield S P, Curwain B P, Spencer J
出版信息
Acta Hepatogastroenterol (Stuttg). 1978 Apr;25(2):155-7.
The involvement of calcium ions in stimulus-secretion coupling in the gastric mucosa is uncertain. Acid secretion and mucosal cyclic nucleotide content of an isolated stomach preparation from the guinea-pig have been measured in the presence of the ionophore A2318 (Lilly) over the concentration range 10(-6) M both in the presence and absence of a phosphodiesterase inhibitor (ICI 631978 1 X 10(-4) M). The rate of acid secretion and cyclic nucleotide content were increased by ICI 63197 as expected but were unaltered by the ionophore. These results suggest that a change in intracellular calcium ion concentration does not alter acid secretion in this preparation.
钙离子在胃黏膜刺激-分泌偶联中的作用尚不确定。在有无磷酸二酯酶抑制剂（ICI 631978，1×10⁻⁴ M）的情况下，于10⁻⁶ M浓度范围内，使用离子载体A2318（礼来公司产品）测定了豚鼠离体胃制剂的酸分泌和黏膜环核苷酸含量。如预期的那样，ICI 63197使酸分泌速率和环核苷酸含量增加，但离子载体对其无影响。这些结果表明，在该制剂中细胞内钙离子浓度的变化不会改变酸分泌。
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