Department of Psychiatry and Psychology, College of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Beijing HuiLongGuan Hospital, Peking University HuiLongGuan Clinical Medical School, Beijing, China.
Asian J Psychiatr. 2022 Mar;69:103003. doi: 10.1016/j.ajp.2022.103003. Epub 2022 Jan 4.
Few studies have compared serum BDNF and glycolipid profiles in patients with deficit schizophrenia (DS) and non-deficit schizophrenia (NDS). We aimed to compare BDNF and glycolipid profiles between DS and NDS patients and healthy controls, and to investigate the relationship between BDNF, glycolipid profiles in DS and NDS patients.
A total of 591 patients with chronic schizophrenia (SZ) and 238 healthy controls participated in this study. According to Proxy for the Deficit Syndrome Scale, SZ patients were divided into DS (n = 158) and NDS (n = 273) patients. Psychiatric symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS). Serum BDNF levels were measured using enzyme-linked immunosorbent assay (ELISA).
BDNF levels were significantly lower in SZ patients than those in healthy controls (7.81 ± 2.98 ng/ml vs. 11.96 ± 2.29 ng/ml, P < 0.01). Furthermore, BDNF levels were lower in DS group than those in NDS group (P = 0.007, OR = 0.846, 95% CI = 0.750-0.955). Lower triglyceride levels were also an independent predictor for DS patients (P = 0.007, OR = 0.846, 95% CI = 0.750-0.955). Serum BDNF levels were negatively associated with the severity of deficit syndrome in SZ patients (β = -1.151, t = -2.559, P = 0.011). In DS group, triglycerides were associated with PANSS negative subscore (β = -0.262, t = -2.994, P = 0.003) and depressive factor subscore (β = 0.282, t = 2.146, P = 0.035).
Serum BDNF and triglycerides may be informative biomarkers of DS in SZ patients. The differences in glycolipid metabolism patterns between DS and NDS patients indicate that deficit syndrome is an independent endophenotype of SZ patients.
很少有研究比较过缺陷型精神分裂症（DS）和非缺陷型精神分裂症（NDS）患者的血清脑源性神经营养因子（BDNF）和糖脂谱。我们旨在比较 DS 和 NDS 患者与健康对照组之间的 BDNF 和糖脂谱，并探讨 DS 和 NDS 患者的 BDNF 与糖脂谱之间的关系。
共有 591 名慢性精神分裂症（SZ）患者和 238 名健康对照者参与了这项研究。根据缺陷综合征量表，SZ 患者被分为 DS（n=158）和 NDS（n=273）患者。使用阳性和阴性综合征量表（PANSS）评估精神病症状。采用酶联免疫吸附试验（ELISA）测定血清 BDNF 水平。
与健康对照组相比，SZ 患者的 BDNF 水平显著降低（7.81±2.98ng/ml 比 11.96±2.29ng/ml，P<0.01）。此外，DS 组的 BDNF 水平低于 NDS 组（P=0.007，OR=0.846，95%CI=0.750-0.955）。较低的甘油三酯水平也是 DS 患者的独立预测因素（P=0.007，OR=0.846，95%CI=0.750-0.955）。血清 BDNF 水平与 SZ 患者缺陷综合征的严重程度呈负相关（β=-1.151，t=-2.559，P=0.011）。在 DS 组中，甘油三酯与 PANSS 阴性子量表（β=-0.262，t=-2.994，P=0.003）和抑郁因子子量表（β=0.282，t=2.146，P=0.035）呈负相关。
血清 BDNF 和甘油三酯可能是 SZ 患者 DS 的有价值的生物标志物。DS 和 NDS 患者之间糖脂代谢模式的差异表明，缺陷综合征是 SZ 患者的一个独立表型。
