邻水杨酸对正常及葡萄糖-6-磷酸脱氢酶缺乏的红细胞中磷酸戊糖途径活性的影响。
The effect of o-salicylate upon pentose phosphate pathway activity in normal and G6PD-deficient red cells.
作者信息
Worathumrong N, Grimes A J
出版信息
Br J Haematol. 1975 Jun;30(2):225-31. doi: 10.1111/j.1365-2141.1975.tb00536.x.
PMID:35
Abstract
The effect of the major metabolite of aspirin, namely salicylic acid, upon the pentose phosphate pathway (PPP) of normal and G6PD-deficient red cells has been studied. Salicylic acid was shown to inhibit this pathway in proportion to the amount present. At any concentration of this substance there was greater inhibition of the PPP in G6PD-deficient than in normal red cells.
摘要
已对阿司匹林的主要代谢产物即水杨酸对正常红细胞和葡萄糖-6-磷酸脱氢酶（G6PD）缺乏的红细胞的磷酸戊糖途径（PPP）的影响进行了研究。结果表明，水杨酸对该途径的抑制作用与存在的量成正比。在该物质的任何浓度下，G6PD缺乏的红细胞中PPP受到的抑制都比正常红细胞中的更大。
Zotero 插件