Suppr超能文献

一名患有肺动脉高压的患者在大流行期间等待供肺:体外生命支持 194 天,其中肺动脉至左心房分流术 143 天。

A patient with pulmonary hypertension waiting for donor lungs during the pandemic: 194 days on extracorporeal life support including 143 days on pulmonary artery to left atrium shunt.

机构信息

Department of Anaesthesiology and Intensive Care, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia.

Department of Anaesthesiology and Intensive Care, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czechia.

出版信息

Am J Transplant. 2022 Aug;22(8):2094-2098. doi: 10.1111/ajt.16949. Epub 2022 Jan 19.

Abstract

Patients with pulmonary hypertension and end-stage lung disease are fraught with high mortality while on a waiting list for lung transplant. With sometimes rapid deterioration they may require veno-arterial extracorporeal membrane oxygenation (VA-ECMO) as an immediate life-saving technique, which is a time-limited solution. The technique of pulmonary artery to left atrium (PA-LA) shunt fitted with an oxygenator enables bridging the patient to transplant for a longer time period. This low-resistance paracorporeal pumpless lung assist device allows for de-adaptation of the right ventricle back to lower afterload before the lung transplantation is carried out. The PA-LA shunt with an oxygenator also conveys a risk of multiple complications with reported median of 10-26 days until transplant. We report a case of pulmonary capillary hemangiomatosis in a 35-year-old female who had to wait for donor lungs during the pandemic of SARS-CoV-2 for 143 days on PA-LA shunt with oxygenator following 51 days on VA-ECMO. The extremely long course associated with multiple complications including three cerebral embolisms, episodes of sepsis and ingrowth of the return cannula into the left ventricular wall gives insight into the limits of this bridging technique.

摘要

患有肺动脉高压和终末期肺病的患者在等待肺移植时死亡率很高。由于病情迅速恶化,他们可能需要立即进行静脉-动脉体外膜肺氧合(VA-ECMO)作为救命技术,这是一种限时解决方案。肺动脉至左心房(PA-LA)分流器与氧合器配合使用,可以使患者在更长的时间内桥接至移植。这种低阻力的体外无泵肺辅助装置可以使右心室在进行肺移植前重新适应较低的后负荷。带氧合器的 PA-LA 分流器也会带来多种并发症的风险,据报道,在移植前有 10-26 天的中位时间。我们报告了一例 35 岁女性肺毛细血管血管瘤病的病例,在 SARS-CoV-2 大流行期间,她在等待供肺,在接受 51 天 VA-ECMO 后,通过带氧合器的 PA-LA 分流器等待了 143 天。由于与多种并发症相关的极其漫长的病程,包括三次脑栓塞、败血症发作和回流插管植入左心室壁,这让我们深入了解了这种桥接技术的局限性。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验