Olgun Esin Gizem, Cetin Sirmen Kizilcan, Siklar Zeynep, Aycan Zehra, Ozsu Elif, Ceran Aysegul, Berberoglu Merih
Department of Pediatrics, School of Medicine, Ankara University, Ankara, Turkey.
Department of Pediatric Endocrinology, School of Medicine, Ankara University, Ankara, Turkey.
Clin Pediatr Endocrinol. 2022;31(1):25-32. doi: 10.1297/cpe.2021-0042. Epub 2021 Nov 1.
We aimed to determine the prevalence of early puberty in girls with premature pubarche and analyze the time interval between their pubarche and succeeding thelarche. This study included 60 female children with premature pubarche. We retrospectively collected clinical, laboratory, and radiological findings from all participants. We investigated the time interval between pubarche and thelarche in cases wherein premature pubarche was followed by thelarche. The mean age at onset of pubarche was 6.93 ± 0.79 yr old. Among the participants, 16.7% were preterm, 20% were small for gestational age (SGA), and 55% were overweight or obese. The mean time interval between pubarche and thelarche was 11.20 ± 7.41 mo. The mean serum DHEA-S level was higher in the preterm group (p = 0.016), and DHEA-S levels were generally higher in the SGA group (p = 0.004). This study documented the presence of being overweight or obese and having more advanced growth than their genetic potential in half of the patients who had premature pubarche. In addition to these identified risk factors, obesity-independent DHEA-S levels were observed to be higher in patients who had early puberty with the first six months of their follow-up considered to be the most critical time in predicting early puberty.
我们旨在确定阴毛早现女童青春期提前的患病率，并分析其阴毛早现与随后乳房发育之间的时间间隔。本研究纳入了60名阴毛早现的女童。我们回顾性收集了所有参与者的临床、实验室和影像学检查结果。我们调查了阴毛早现后出现乳房发育的病例中阴毛早现与乳房发育之间的时间间隔。阴毛早现开始时的平均年龄为6.93±0.79岁。参与者中，16.7%为早产儿，20%为小于胎龄儿（SGA），55%超重或肥胖。阴毛早现与乳房发育之间的平均时间间隔为11.20±7.41个月。早产儿组的平均血清硫酸脱氢表雄酮（DHEA-S）水平较高（p=0.016），SGA组的DHEA-S水平总体上也较高（p=0.004）。本研究记录了一半阴毛早现患者存在超重或肥胖以及生长超过其遗传潜能的情况。除了这些已确定的风险因素外，观察到青春期提前患者的肥胖无关DHEA-S水平较高，随访的前六个月被认为是预测青春期提前的最关键时期。
