希腊青少年月经初潮年龄较小，但与体重指数无关。

Indications of younger age at menarche in Greek adolescents but with no relation to body mass index.

作者信息

Papageorgiou Anastasia, Charmandari Evangelia, Efthymiou Vasiliki, Vlachakis Dimitrios, Bacopoulou Flora

机构信息

Center for Adolescent Medicine and UNESCO Chair in Adolescent Health Care, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, 1 Thivon Street, Goudi, Athens, 11527, Greece.

First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, Aghia Sophia Children's Hospital, Athens, 11527, Greece.

出版信息

Hormones (Athens). 2024 Sep;23(3):527-534. doi: 10.1007/s42000-024-00557-8. Epub 2024 Apr 22.

DOI:10.1007/s42000-024-00557-8

PMID:38647964

Abstract

PURPOSE

This study aimed to present recent trends in the pubertal timing of a Greek female sample.

METHODS

Data were collected retrospectively from medical records of healthy females aged 6-18 years who attended a tertiary Adolescent Friendly Health Center over a 5-year period (2016-2020) and included gestational age, birth anthropometrics, and age of thelarche and/or pubarche and/or menarche, along with corresponding anthropometric, hormonal, and biochemical measurements.

RESULTS

Data from 298 girls' medical records were included in the analysis. Median age at menarche, thelarche, and pubarche was 12, 9, and 9 years, respectively. The mean interval between pubertal onset and menarche was 1.99 years. The mean body mass index (BMI) at menarche and thelarche was 20.99 kg/m and 18.90 kg/m, respectively. The mean weight at menarche was 49.6 kg, whereas the mean height difference between thelarche and menarche was 19.17 cm. Among participants, 6.3% had premature menarche, while 24.0% had premature thelarche. Birth weight was moderately correlated with BMI at thelarche/pubarche (r=0.334, p = 0.005). Birth weight and BMI at thelarche/pubarche were not predictive of premature menarche or premature thelarche. Median (interquartile range, IQR) levels at menarche vs. thelarche were significantly higher for insulin-like growth factor-1 [358.00 (140.50) vs. 176.00 (55.00) ng/ml], follicle stimulation hormone [5.65 (3.14) vs. 3.10 (4.23) mIU/ml], testosterone [25.50 (31.00) vs. 13.00 (21.00) ng/dl], dehydroepiandrosterone sulfate [117.00 (112.50) vs. 46.40 (51.90) µg/dl], and insulin [17.40 (15.05) vs. 8.47 (4.97) µIU/ml].

CONCLUSION

The timing of pubertal stages in the Greek female sample studied followed the recent international downward trends. Younger age at menarche was not related to BMI.

摘要

目的

本研究旨在呈现希腊女性样本青春期发育时间的近期趋势。

方法

回顾性收集了2016年至2020年期间在一家三级青少年友好健康中心就诊的6至18岁健康女性的病历数据，包括胎龄、出生时人体测量数据、乳房初发育和/或阴毛初现和/或月经初潮的年龄，以及相应的人体测量、激素和生化指标。

结果

分析纳入了298名女孩的病历数据。月经初潮、乳房初发育和阴毛初现的中位年龄分别为12岁、9岁和9岁。青春期开始至月经初潮的平均间隔为1.99年。月经初潮和乳房初发育时的平均体重指数（BMI）分别为20.99kg/m²和18.90kg/m²。月经初潮时的平均体重为49.6kg，而乳房初发育至月经初潮的平均身高差为19.17cm。参与者中，6.3%月经初潮过早，24.0%乳房初发育过早。出生体重与乳房初发育/阴毛初现时的BMI呈中度相关（r = 0.334，p = 0.005）。出生体重和乳房初发育/阴毛初现时的BMI不能预测月经初潮过早或乳房初发育过早。月经初潮与乳房初发育时胰岛素样生长因子-1[358.00（140.50）对176.00（55.00）ng/ml]、促卵泡激素[5.65（3.14）对3.10（4.23）mIU/ml]、睾酮[25.50（31.00）对13.00（21.00）ng/dl]、硫酸脱氢表雄酮[117.00（112.50）对46.40（51.90）μg/dl]和胰岛素[17.40（15.05）对8.47（4.97）μIU/ml]的中位数（四分位间距，IQR）水平显著更高。