Behl Tapan, Chadha Swati, Sehgal Aayush, Singh Sukhbir, Sharma Neelam, Kaur Rajwinder, Bhatia Saurabh, Al-Harrasi Ahmed, Chigurupati Sridevi, Alhowail Ahmed, Bungau Simona
Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Natural & Medical Sciences Research Centre, University of Nizwa, Nizwa, Oman.
Saudi J Biol Sci. 2022 Jan;29(1):402-410. doi: 10.1016/j.sjbs.2021.09.014. Epub 2021 Sep 13.
Rheumatoid arthritis (RA) is a chronic inflammatory disease which is marked by leukocytes infiltration inside synovial tissue, joints and also inside synovial fluid which causes progressive destruction of joint cartilage. There are numerous genetical and lifestyle factors, responsible for rheumatoid arthritis. One such factor can be cysteine cathepsins, which act as proteolytic enzymes. These proteolytic enzyme gets activated at acidic pH and are found in lysosomes and are also termed as cysteine proteases. These proteases belong to papain family and have their elucidated role in musculoskeletal disorders. Numerous cathepsins have their targeted role in rheumatoid arthritis. These proteases are secreted through various cell types which includes matrix metalloproteases and papain like cysteine proteases. These proteases can potentially lead to bone and cartilage destruction which causes an immune response in case of inflammatory arthritis.
类风湿性关节炎（RA）是一种慢性炎症性疾病，其特征是白细胞浸润滑膜组织、关节以及滑膜液，导致关节软骨进行性破坏。有许多遗传和生活方式因素与类风湿性关节炎有关。其中一个因素可能是半胱氨酸组织蛋白酶，它作为蛋白水解酶起作用。这些蛋白水解酶在酸性pH值下被激活，存在于溶酶体中，也被称为半胱氨酸蛋白酶。这些蛋白酶属于木瓜蛋白酶家族，在肌肉骨骼疾病中发挥着明确的作用。许多组织蛋白酶在类风湿性关节炎中具有靶向作用。这些蛋白酶通过多种细胞类型分泌，包括基质金属蛋白酶和木瓜蛋白酶样半胱氨酸蛋白酶。这些蛋白酶可能导致骨骼和软骨破坏，在炎症性关节炎的情况下引发免疫反应。
