Hammond Christopher J, Krishnan-Sarin Suchitra, Mayes Linda C, Potenza Marc N, Crowley Michael J
Division of Child & Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Int J Ment Health Addict. 2021 Dec;19(6):1963-1979. doi: 10.1007/s11469-020-00292-2. Epub 2020 May 15.
Cannabis and tobacco use and related disorders have been separately associated with sensitivity to reward (SR), sensitivity to punishment (SP), and impulsivity. Given the frequent co-occurrence of cannabis and tobacco consumption in adolescents, it is important to understand how SR, SP and impulsivity may relate to both cannabis-use and tobacco-use co-occurrences and problem severities. Presently, sixty-five adolescents (14-21 years, 65% male), including 36 adolescents with daily tobacco smoking and regular cannabis use and 29 non-smoking healthy controls (HCs), completed self-report questionnaires assessing substance use, addiction severity, SR, SP, and impulsivity. Adolescent smokers had decreased SP and increased impulsivity compared to HCs. SR and impulsivity were independent predictors of concurrent cannabis-related problem severity among smokers. These findings suggest that specific approach/avoidance motives and impulsivity warrant further investigation as potential treatment targets in adolescents who consume both tobacco and cannabis.
大麻和烟草使用及相关障碍分别与奖赏敏感性（SR）、惩罚敏感性（SP）和冲动性有关。鉴于青少年中大麻和烟草消费经常同时出现，了解SR、SP和冲动性如何与大麻使用和烟草使用的同时出现及问题严重程度相关很重要。目前，65名青少年（14 - 21岁，65%为男性），包括36名每日吸烟且经常使用大麻的青少年和29名不吸烟的健康对照者（HCs），完成了评估物质使用、成瘾严重程度、SR、SP和冲动性的自我报告问卷。与HCs相比，青少年吸烟者的SP降低且冲动性增加。SR和冲动性是吸烟者中并发大麻相关问题严重程度的独立预测因素。这些发现表明，特定的趋近/回避动机和冲动性作为同时消费烟草和大麻的青少年潜在治疗靶点值得进一步研究。
