成纤维细胞生长因子2在听觉系统发育和再生中的分子及临床意义
Molecular and Clinical Significance of Fibroblast Growth Factor 2 in Development and Regeneration of the Auditory System.
作者信息
Jeong Minjin, Bojkovic Katarina, Sagi Varun, Stankovic Konstantina M
机构信息
Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, United States.
Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, United States.
出版信息
Front Mol Neurosci. 2021 Dec 23;14:757441. doi: 10.3389/fnmol.2021.757441. eCollection 2021.
The fibroblast growth factor 2 (FGF2) is a member of the FGF family which is involved in key biological processes including development, cellular proliferation, wound healing, and angiogenesis. Although the utility of the FGF family as therapeutic agents has attracted attention, and FGF2 has been studied in several clinical contexts, there remains an incomplete understanding of the molecular and clinical function of FGF2 in the auditory system. In this review, we highlight the role of FGF2 in inner ear development and hearing protection and present relevant clinical studies for tympanic membrane (TM) repair. We conclude by discussing the future implications of FGF2 as a potential therapeutic agent.
成纤维细胞生长因子2（FGF2）是FGF家族的成员，参与包括发育、细胞增殖、伤口愈合和血管生成在内的关键生物学过程。尽管FGF家族作为治疗剂的效用已引起关注，并且FGF2已在多种临床背景下进行了研究，但对FGF2在听觉系统中的分子和临床功能仍存在不完全的了解。在本综述中，我们强调了FGF2在内耳发育和听力保护中的作用，并介绍了鼓膜（TM）修复的相关临床研究。我们通过讨论FGF2作为潜在治疗剂的未来意义来结束本文。
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