Anderson T W
Acta Vitaminol Enzymol. 1977;31(1-5):43-50.
The combination of a regular daily supplement of vitamin C with extra dosage at the time of illness has been shown to reduce the disability due to common colds and other winter illness, but we have seen little effect on frequency of infections, sense of (well-being), or levels of serum cholesterol. The variable results that have been obtained from some other trials of vitamin C may be due in part to variation in the initial nutritional state of the subjects, with the greatest effects to be expected where there is most room for improvement. Because of the great variation in individual susceptibility to infection large numbers of subjects are required in these trials and they must be strictly double-blind. Although we have seen no clear evidence of harmful side-effects, occasional sensitivity to large doses of vitamin C cannot be ruled out, and the withdrawal depression of blood levels could conceivably interfere with a patient's ability to handle stress.
日常规律补充维生素C并在生病时额外增加剂量，已被证明可减少因普通感冒和其他冬季疾病导致的身体不适，但我们尚未发现其对感染频率、健康感或血清胆固醇水平有显著影响。其他一些维生素C试验得到的结果各异，部分原因可能是受试者初始营养状态存在差异，改善空间最大的人群预期效果最佳。由于个体对感染的易感性差异极大，此类试验需要大量受试者，且必须严格进行双盲试验。尽管我们尚未发现明显的有害副作用证据，但不能排除偶尔对大剂量维生素C敏感的情况，而且血液水平的下降可能会干扰患者应对压力的能力。
