Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Front Immunol. 2021 Dec 23;12:808064. doi: 10.3389/fimmu.2021.808064. eCollection 2021.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy is associated with a higher risk for severe morbidity and mortality when compared with infection in non-pregnant women of childbearing age. An increasing number of countries recommend immunization against SARS-CoV-2 in pregnant women. Recent studies provide preliminary and supportive evidence on safety, immunogenicity and effectiveness of coronavirus disease 2019 (COVID-19) vaccines in pregnant women; however, important knowledge gaps remain which warrant further studies. This collaborative consensus paper provides a review of the current literature on COVID-19 vaccines in pregnant women, identifies knowledge gaps and outlines priorities for future research to optimize protection against SARS-CoV-2 in the pregnant women and their infants.
严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)感染在妊娠时与非妊娠育龄妇女相比,与严重发病率和死亡率风险增加相关。越来越多的国家建议孕妇接种 SARS-CoV-2 疫苗。最近的研究为在孕妇中使用 COVID-19 疫苗的安全性、免疫原性和有效性提供了初步和支持性证据;然而,仍存在重要的知识空白,需要进一步研究。本合作共识文件对当前关于孕妇 COVID-19 疫苗的文献进行了综述,确定了知识空白,并概述了未来研究的优先事项,以优化孕妇及其婴儿对 SARS-CoV-2 的保护。