Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Immunol. 2021 Dec 23;12:808420. doi: 10.3389/fimmu.2021.808420. eCollection 2021.
Demyelination diseases are complex puzzles that are not always straightforward to diagnose. Multiple sclerosis and neuromyelitis optica are two that are frequently encountered. Numerous autoantibodies newly discovered in recent years have significantly aided clinical reasoning and diagnosis in differentiating demyelination disorders. Here we report a case of demyelination disease with anti-flotillin autoantibodies positive, which is not common in past references.
The patient presented with characteristic neuromyelitis optica symptoms and had remission and relapse. But his images exhibited characteristics of both neuromyelitis optica spectrum illness and multiple sclerosis.
This is the first case report describing the clinical course and imaging characteristics of demyelination illness associated with anti-flotillin autoantibodies. Although so far it appears to be a subtype of multiple sclerosis, there is still a potential that it is separate from MS and NMOSD.
脱髓鞘疾病是复杂的谜题，并不总是易于诊断。多发性硬化症和视神经脊髓炎是两种常见的疾病。近年来新发现的许多自身抗体极大地帮助了临床推理和诊断，有助于区分脱髓鞘疾病。在这里，我们报告了一例抗 flotillin 自身抗体阳性的脱髓鞘疾病病例，这在以往的参考文献中并不常见。
患者表现出典型的视神经脊髓炎症状，有缓解和复发。但他的影像表现既有视神经脊髓炎谱疾病的特征，也有多发性硬化症的特征。
这是首例描述抗 flotillin 自身抗体相关脱髓鞘疾病的临床病程和影像学特征的病例报告。尽管迄今为止，它似乎是多发性硬化症的一个亚型，但仍有可能与 MS 和 NMOSD 不同。
