Shebli Baraa, Batal Rand, Chihab Mtanyous, Zammar Leen, Warrak Bayan, Allouzi Sana, Abdullah Manar
Department of Cardiology, Aleppo University Hospital, University of Aleppo, Syria.
Department of Pathology, Aleppo University Hospital, University of Aleppo, Syria.
Ann Med Surg (Lond). 2021 Dec 21;73:103196. doi: 10.1016/j.amsu.2021.103196. eCollection 2022 Jan.
and importance: Brucellosis is a common infection in Mediterranean region that manifests with various symptoms. Brucellosis should be considered as a possible cause of recurrent fever even if the symptoms are not suggestive of brucellosis.
We report a case of 10-year-old child with no significant past medical history who presented with a 4-day period peripheral edema and ascites without fever, arthralgia or abdominal pain.
Proper investigations showed normal cardiac and renal functions; ultrasonography showed no portal vein hypertension. Albumin and total protein were also within normal. Complete blood count revealed pancytopenia; bone marrow aspiration and biopsy revealed hypercellularity that could be attributed to hypersplenism as a possible cause. Liver biopsy revealed non-specific inflammatory findings and also did not lead to a definite diagnosis. While broadening the scope of deferential diagnosis in order to reach a final diagnosis, Wright serum agglutination was tested positive (1/640) and we diagnosed a brucellosis infection. A proper management with Antibiotics ensued; the patient had uneventful recovery on treatment until complete clinical and imaging resolution of signs and symptoms.
Although brucellosis is considered a multi-systemic disease with atypical presentations, early diagnosis of brucellosis with management causes rapid recovery and favorable prognosis. We report a case of ascites and edema in context of Brucella infection which was completely resolved after treatment. This condition is rare especially in previously healthy child and after excluding other possible causes. We aim to share our case to keep brucellosis in mind as a differential diagnosis when dealing with infectious diseases with non-specific symptoms.
及重要性:布鲁氏菌病在地中海地区是一种常见感染,表现出多种症状。即使症状不提示布鲁氏菌病,也应将其视为反复发热的可能病因。
我们报告一例10岁儿童,既往无重大病史,出现为期4天的外周水肿和腹水,无发热、关节痛或腹痛。
适当检查显示心脏和肾功能正常;超声检查未显示门静脉高压。白蛋白和总蛋白也在正常范围内。全血细胞计数显示全血细胞减少;骨髓穿刺和活检显示细胞增多,这可能归因于脾功能亢进这一可能病因。肝活检显示非特异性炎症表现,也未得出明确诊断。在扩大鉴别诊断范围以达成最终诊断时,wright血清凝集试验呈阳性(1/640),我们诊断为布鲁氏菌病感染。随后进行了适当的抗生素治疗;患者在治疗过程中恢复顺利,直至体征和症状在临床和影像学上完全消退。
尽管布鲁氏菌病被认为是一种具有非典型表现的多系统疾病,但早期诊断并治疗布鲁氏菌病可实现快速康复和良好预后。我们报告一例布鲁氏菌感染导致腹水和水肿的病例,经治疗后完全消退。这种情况很罕见,尤其是在既往健康的儿童中,且在排除其他可能病因之后。我们旨在分享我们的病例,以便在处理具有非特异性症状的传染病时,将布鲁氏菌病作为鉴别诊断予以考虑。