布鲁氏菌病患儿的全血细胞减少症：临床表现及骨髓检查结果

Pancytopenia in children with brucellosis: clinical manifestations and bone marrow findings.

作者信息

al-Eissa Y A, Assuhaimi S A, al-Fawaz I M, Higgy K E, al-Nasser M N, al-Mobaireek K F

机构信息

Department of Paediatrics, King Saud University, Riyadh, Saudi Arabia.

出版信息

Acta Haematol. 1993;89(3):132-6. doi: 10.1159/000204504.

DOI:10.1159/000204504

PMID:8362601

Abstract

Among 276 paediatric cases of brucellosis seen over a 7-year period, 16 patients (5.8%) with pancytopenia were identified. The most frequent presentations were fever, malaise, anorexia, weight loss, arthralgia, and hepatosplenomegaly. Fourteen patients (87.5%) had positive blood and/or bone marrow cultures for Brucella melitensis. Bone marrow aspiration specimens showed hypercellularity in 14 patients and normocellularity in 2. Histiocytes, eosinophils and plasma cells were increased in every marrow aspirate, and haemophagocytosis was observed in 14 patients (87.5%). Non-caseating granulomas were present in the bone marrow biopsy of 11 patients (68.8%). The pancytopenia was transient, and resolved on treatment of the Brucella infection.

摘要

在7年期间诊治的276例小儿布鲁氏菌病病例中，确诊16例（5.8%）全血细胞减少患者。最常见的症状为发热、不适、厌食、体重减轻、关节痛和肝脾肿大。14例（87.5%）患者血培养和/或骨髓培养出羊种布鲁氏菌阳性。14例患者骨髓穿刺标本显示细胞增多，2例正常细胞。每次骨髓穿刺中组织细胞、嗜酸性粒细胞和浆细胞均增多，14例患者（87.5%）观察到噬血细胞现象。11例患者（68.8%）骨髓活检有非干酪样肉芽肿。全血细胞减少是暂时的，在布鲁氏菌感染治疗后缓解。